Vascular Metabolism

Faculty

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Research Focus

The Vascular Metabolism Laboratory focuses on the molecular and metabolic drivers of obesity and heart failure. Our research investigates how vascular and skeletal muscle dysfunction contribute to exercise intolerance. We also explore the mechanisms by which novel therapeutic interventions may help reverse physical dysfunction in heart failure.

About this Lab

This lab is supported by an NIH-funded Metabolic Basis for Disease research project award. The primary focus is investigating the role of hydrogen sulfide signaling in exercise intolerance in heart failure with preserved ejection fraction (HFpEF). The lab uses murine models with both genetic deletion and overexpression of hydrogen sulfide–related enzymes to explore these mechanisms. The Vascular Metabolism team employs state-of-the-art tools, including metabolic cage systems for preclinical heart failure phenotyping, as well as microdialysis and laser speckle contrast imaging to assess blood flow and microcirculation metabolism. The lab also features specialized expertise in uncovering the mechanisms of exercise training adaptations in skeletal muscle, the heart, and adipose tissue.