Integrated Physiology and Molecular Medicine Laboratory

Leadership

John Kirwan, PhD

John Kirwan, PhD
Principal Investigator

Christopher L. Axelrod, MS

Christopher L. Axelrod, MS
Director

Laboratory Members

 

Kathryn Belmont, MS

Kathryn Belmont, MS
Lab Manager

Patricia Baumgarten, PhD

Bolormaa Vandanmagsar, PhD
Senior Scientist

Elizabeth Heintz, MS

Elizabeth Heintz, MS
PhD Candidate

Analisa Taylor, MS

Analisa Taylor
PhD Candidate

 

Elizabeth R. M. Zunica, MS

Elizabeth R. M. Zunica, MS
Postdoctoral Fellow

Patricia Baumgarten, PhD

Patricia Baumgarten, PhD
Postdoctoral Fellow

Calley Chauvin

Calley Chauvin
LSU

Anan L. Cole

Anan L. Cole
LSU

 

Noah J. Gibson

Noah J. Gibson
LSU

Christine Nguyen

Christine Nguyen
LSU

 

Research Focus

Our laboratory is focused on improving the quality of life of patients with obesity-related diseases. We achieve this by translating clinical observations into basic scientific discoveries to be leveraged for development of more effective treatments.

About this Lab

The Integrated Physiology and Molecular Medicine Laboratory seeks to identify causes, consequences, and interventions for metabolic diseases. We employ basic, translational, and clinical research to discover novel therapies and optimize existing treatments for obesity-related diseases Overarching research interests include regulation of insulin sensitivity, glucose and lipid metabolism, mitochondrial function, obesity, type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular complications, aging and lifespan, cancer, exercise, metabolic surgery, and drug discovery.

 


Laboratory Member Bios

  • BA Kinesiology
    University of Limerick, 1980
  • MSc Exercise Biochemistry
    University of Massachusetts, 1984
  • PhD Human Bioenergetics
    Ball State University, 1987
  • Postdoctoral Fellow
    Washington University School of Medicine, 1991
  • Visiting Scholar
    University of California San Diego, 2004

Dr. John Kirwan is the principal investigator of the IPMM laboratory and executive director of Pennington BIomedical Research Center. As a Clinical Translational scientist, Dr. Kirwan has maintained an independent and productive program pursuing research related to obesity, diabetes, and metabolism for over 25 years. Dr. Kirwan’s research interests include the underlying pathophysiology of type 2 diabetes and identification of lifestyle, surgical, and pharmacological interventions that facilitate weight loss and improve insulin sensitivity.

  • Visiting Scholar
    University of Legon, 2010
  • BA Public Health
    John Carroll University, 2011
  • MS Exercise Physiology
    Cleveland State University, 2016

Christopher Axelrod is the director of the IPMM laboratory. Christopher oversees day-to-day operation of the clinical, pre-clinical, and discovery-based programs. His research applies a bioenergetic lens to understanding the pathogenesis and treatment of complex metabolic diseases such as insulin resistance, obesity, type 2 diabetes, non-alcoholic fatty liver disease, and cancer. Current interests include development and testing of mitochondrial targeted pharmacotherapies, redox homeostasis in aging and disease, and therapeutic applications of metabolic surgery.

  • BS Biology
    University of New Orleans, 2014
  • MS Kinesiology
    Louisiana State University, 2023 (anticipated)

Kathryn Belmont is the manager of the IPMM laboratory. Kathryn oversees daily operation of the research laboratory and serves as an anchor between our basic, pre-clinical, and clinical research programs.

  • MS/Physician Biology
    Russian State Medical University, 1994
  • PhD Genetics
    Peoples’ Friendship University of Russia, 2001
  • Visiting Scholar
    Yonsei University, 2004
  • Postdoctoral Fellow
    National Institute on Aging, 2008
  • Postdoctoral Fellow
    Pennington Biomedical Research Center, 2012

Dr. Bolormaa Vandanmagsar is an assistant professor of research in the IPMM laboratory. Her work is focused on the link between chronic inflammation and obesity, obesity-associated insulin resistance, particularly, the association between muscle inflammation and skeletal muscle insulin resistance, and the role of metabolic states in the development of inflammation in muscle. Dr. Vandanmagsar is also interested in how skeletal muscle signals to other metabolic organs such as liver and pancreas when metabolic stress is present.

  • BS Biochemistry
    John Carroll University, 2010
  • MS Nutrition
    Case Western Reserve University, 2017
  • PhD Nutrition
    Case Western Reserve University, 2021 (Anticipated)

Elizabeth Zunica is a postdoctoral research fellow in the IPMM laboratory. Elizabeth obtained her PhD from Case Western Reserve University in 2022 in Nutritional Biochemistry. Her current work is focused on mechanisms underlying the progression of steatotic liver disease to liver cancer. Elizabeth has a broad interest in cellular metabolism and nutritional biochemistry with a focus on changes in mitochondrial function associated with disease and in response to therapeutic interventions.

  • PhD Physiology
    University of Potsdam, 2025

Dr. Patricia Baumgarten is a postdoctoral research fellow in the IPMM laboratory. Patricia obtained her PhD from The University of Potsdam in 2025 in Physiology. Her current work is focused on pathophysiology and mechanisms associated with sarcopenic obesity. Patricia has a broad interest in changes in metabolism associated with aging, with specific focus on how quality control/repair mechanisms influence disease acceleration and outcomes. 

  • BS Kinesiology
    University of Louisiana, 2019
  • MS Kinesiology
    University of Louisiana, 2021
  • PhD Kinesiology
    Louisiana State University, 2026 (Anticipated)

Elizabeth Heintz is a doctoral candidate at Louisiana State University in the Department of Kinesiology. Her current work is focused on the role of mitochondrial solute carriers in the regulation of non-alcoholic fatty liver disease. Elizabeth has a broader interest in exercise physiology with a focus on mitochondrial adaptations associated with aging and chronic disease.

  • BS Biology
    Louisiana State University, 2022
  • PhD Genetics and Genome Sciences
    Case Western Reserve University (Anticipated)

Analisa Taylor is a doctoral candidate at Case Western Reserve University in the Department of Genetics. Her current work is focused on the role and regulation of mitochondrial Rho GTPases in the context of obesity and type 2 diabetes. Analisa has a broader interest in genetics and the development of genetic models to understand causes and consequences of insulin resistance and type 2 diabetes.

Calley Chauvin
Louisiana State University

Anan L. Cole
Louisiana State University

Noah J. Gibson
Louisiana State University

Christine Nguyen
Louisiana State University


Research In Focus