About This Core
The Transgenic Core currently produces mice for faculty at Pennington Biomedical Research Center as well as investigators at other institutions. The Transgenic Core utilizes pronuclear microinjection with CRISPR cas9 strategies and traditional embryonic stem cell technologies to control gene expression in mice.
The mission of the core is to offer a “turn-key service” for new animal models at PBRC that will allow for the controlled manipulation of gene expression (knock-in point mutations, knock-in of cre recombinase, knock-in of floxed transcriptional blockers, and knock-in of human cDNA, into homologous mouse genes etc) and facilitate investigators in understanding gene function. The core strives to provide services at prices that are below those that are commercially available.