Education
- BS, Chemistry, University of Calcutta, India, 1987
- PhD, Biochemistry, University of Notre Dame, 1992
Research Interests
Dr. Ghosh’s research employs integrative bioinformatics and machine learning tools for investigating the genetic and genomic architectures underlying cardio-metabolic disorders, with a special focus on biological pathways and interaction networks, and with the goal of identifying and functionally validating novel disease gene candidates and biomarkers of disease processes.
Selected Publications
- Hota M, Barber JL, Ruiz-Ramie JJ, Schwartz CS, Lam DTUH, Rao P, Mi MY, Katz DH, Robbins JM, Clish CB, Gerszten RE, Sarzynski MA, Ghosh S, Bouchard C. Omics- driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability. Physiol Genomics. 2023 Nov 1;55(11):517-543. doi: 10.1152/physiolgenomics.00163.2022. Epub 2023 Sep 4. PMID: 37661925.
- Sengottuvel V, Hota M, Oh J, Galam DL, Wong BH, Wenk MR, Ghosh S, Torta F, Silver DL. Deficiency in the omega-3 lysolipid transporter Mfsd2a leads to aberrant oligodendrocyte lineage development and hypomyelination. J Clin Invest. 2023 Jun 15;133(12):e164118. doi: 10.1172/JCI164118. PMID: 37104036; PMCID: PMC10266779.
- Ghosh S, Roy SS. Global-scale modeling of early factors and country-specific trajectories of COVID-19 incidence: a cross-sectional study of the first 6 months of the pandemic. BMC Public Health. 2022 Oct 14;22(1):1919. doi: 10.1186/s12889-022-14336-w. PMID: 36242027; PMCID: PMC9568998.
- Robbins JM, Peterson B, Schranner D, Tahir UA, Rienmüller T, Deng S, Keyes MJ, Katz DH, Beltran PMJ, Barber JL, Baumgartner C, Carr SA, Ghosh S, Shen C, Jennings LL, Ross R, Sarzynski MA, Bouchard C, Gerszten RE. Human plasma proteomic profiles indicative of cardiorespiratory fitness. Nat Metab. 2021 Jun;3(6):786-797. doi: 10.1038/s42255-021-00400-z. Epub 2021 May 27. Erratum in: Nat Metab. 2021 Sep;3(9):1275. PMID: 34045743; PMCID: PMC9216203.
- Fang H, Stone KP, Forney LA, Sims LC, Gutierrez GC, Ghosh S, Gettys TW. Implementation of dietary methionine restriction using casein after selective, oxidative deletion of methionine. iScience. 2021 Apr 24;24(5):102470. doi: 10.1016/j.isci.2021.102470. PMID: 34113817; PMCID: PMC8169944.
- Ghosh S, Wicks SE, Vandanmagsar B, Mendoza TM, Bayless DS, Salbaum JM, Dearth SP, Campagna SR, Mynatt RL, Noland RC. Extensive metabolic remodeling after limiting mitochondrial lipid burden is consistent with an improved metabolic health profile. J Biol Chem. 2019 Aug 16;294(33):12313-12327. doi: 10.1074/jbc.RA118.006074. Epub 2019 May 16. PMID: 31097541; PMCID: PMC6699851.
- Yakala GK, Cabrera-Fuentes HA, Crespo-Avilan GE, Rattanasopa C, Burlacu A, George BL, Anand K, Mayan DC, Corlianò M, Hernández-Reséndiz S, Wu Z, Schwerk AMK, Tan ALJ, Trigueros-Motos L, Chèvre R, Chua T, Kleemann R, Liehn EA, Hausenloy DJ, Ghosh S, Singaraja RR. FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice. Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):387-401. doi: 10.1161/ATVBAHA.118.311903. PMID: 30651003; PMCID: PMC6393193.
- Wilkins J, Ghosh P, Vivar J, Chakraborty B, Ghosh S. Exploring the associations between systemic inflammation, obesity and healthy days: a health related quality of life (HRQOL) analysis of NHANES 2005-2008. BMC Obes. 2018 Aug 6;5:21. doi: 10.1186/s40608-018-0196-2. PMID: 30123515; PMCID: PMC6091152.
- Ghosh S, Bouchard C. Convergence between biological, behavioural and genetic determinants of obesity.Nat Rev Genet. 2017 Dec;18(12):731-748. doi: 10.1038/nrg.2017.72. Epub 2017 Oct 9. PMID: 28989171.
- Ghosh S, Vivar J, Nelson CP, Willenborg C, Segrè AV, Mäkinen VP, Nikpay M, Erdmann J, Blankenberg S, O'Donnell C, März W, Laaksonen R, Stewart AF, Epstein SE, Shah SH, Granger CB, Hazen SL, Kathiresan S, Reilly MP, Yang X, Quertermous T, Samani NJ, Schunkert H, Assimes TL, McPherson R. Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1712-22. doi: 10.1161/ATVBAHA.115.305513. Epub 2015 May 14. PMID: 25977570; PMCID: PMC4841833.
