Education
- BS, Chemistry, University of Calcutta, India, 1987
- PhD, Biochemistry, University of Notre Dame, 1992
Research Interests
Dr. Ghosh’s research employs integrative bioinformatics and machine learning tools for investigating the genetic and genomic architectures underlying cardio-metabolic disorders, with a special focus on biological pathways and interaction networks, and with the goal of identifying and functionally validating novel disease gene candidates and biomarkers of disease processes.
Lab: Functional Genomics
Core: Bioinformatics and Computational Biology
Selected Publications
- Ghosh S, Bouchard C. Considerations on efforts needed to improve our understanding of the genetics of obesity. Int J Obes (Lond). 2025 Feb;49(2):206-210. doi: 10.1038/s41366-024-01528-0. Epub 2024 Jun 7. PMID: 38849463; PMCID: PMC11805711.
- Singh P, Beyl RA, Stephens JM, Richard AJ, Boudreau A, Caitlin Hebert R, Noland RC, Burk DH, Ghosh S, Staszkiewicz J, Michael Salbaum J, Broussard JL, St-Onge MP, Ravussin E, Marlatt KL. Shortened sleep duration impairs adipose tissue adrenergic stimulation of lipolysis in postmenopausal women. Obesity (Silver Spring). 2024 Dec;32(12):2264-2274. doi: 10.1002/oby.24162. Epub 2024 Oct 27. PMID: 39462901; PMCID: PMC11598667.
- Wang L, Seshachalam PV, Chua R, Zhou H, Lei S, Ghosh S. In silico and functional analysis identifies key gene networks and novel gene candidates in obesity-linked human visceral fat. Obesity (Silver Spring). 2024 Nov;32(11):1998-2011. doi: 10.1002/oby.24161. PMID: 39497634; PMCID: PMC11548800.
- Yousefi M, See WR, Aw-Yong KL, Lee WS, Yong CL, Fanusi F, Smith GJD, Ooi EE, Li S, Ghosh S, Ooi YS. GeneRaMeN enables integration, comparison, and meta-analysis of multiple ranked gene lists to identify consensus, unique, and correlated genes. Brief Bioinform. 2024 Jul 25;25(5):bbae452. doi: 10.1093/bib/bbae452. PMID: 39293806; PMCID: PMC11410378.
- Batdorf HM, Lawes LL, Cassagne GA, Fontenot MS, Harvey IC, Richardson JT, Burk DH, Dupuy SD, Karlstad MD, Salbaum JM, Staszkiewicz J, Beyl R, Ghosh S, Burke SJ, Collier JJ. Accelerated onset of diabetes in non-obese diabetic mice fed a refined high-fat diet. Diabetes Obes Metab. 2024 Jun;26(6):2158-2166. doi: 10.1111/dom.15522. Epub 2024 Mar 4. PMID: 38433703; PMCID: PMC11078605
- Li D, Kok CYL, Wang C, Ray D, Osterburg S, Dötsch V, Ghosh S, Sabapathy K. Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73. Proc Natl Acad Sci USA. 2024 May 21;121(21):e2318591121. doi: 10.1073/pnas.2318591121. Epub 2024 May 13. PMID: 38739802; PMCID: PMC11127001.
- Chua R, Wang L, Singaraja R, Ghosh S. Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes. Cells. 2024 Mar 28;13(7):588. doi: 10.3390/cells13070588. PMID: 38607027; PMCID: PMC11154428.
- Hota M, Barber JL, Ruiz-Ramie JJ, Schwartz CS, Lam DTUH, Rao P, Mi MY, Katz DH, Robbins JM, Clish CB, Gerszten RE, Sarzynski MA, Ghosh S, Bouchard C. Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability. Physiol Genomics. 2023 Nov 1;55(11):517-543. doi:10.1152/physiolgenomics.00163.2022. Epub 2023 Sep 4. PMID: 37661925; PMCID: PMC11178266.
- Warfel JD, Elks CM, Bayless DS, Vandanmagsar B, Stone AC, Velasquez SE, Olivares-Nazar P, Noland RC, Ghosh S, Zhang J, Mynatt RL. Rats lacking Ucp1 present a novel translational tool for the investigation of thermogenic adaptation during cold challenge. Acta Physiol (Oxf). 2023 May;238(1):e13935. doi: 10.1111/apha.13935. Epub 2023 Feb 7. PMID: 36650072; PMCID: PMC11318575.
- Martin TM, Burke SJ, Batdorf HM, Burk DH, Ghosh S, Dupuy SD, Karlstad MD, Collier JJ. ICAM-1 Abundance Is Increased in Pancreatic Islets of Hyperglycemic Female NOD Mice and Is Rapidly Upregulated by NF-κB in Pancreatic β-Cells. J Immunol. 2022 Aug 1;209(3):569-581. doi: 10.4049/jimmunol.2200065. PMID: 35851539; PMCID: PMC9845432
