Elizabeth Floyd, Ph.D.Associate Professor
EDUCATIONPh.D., Louisiana State University, Baton Rouge, LA, 1997, Biochemistry
B.S., Univesity of Alabama at Birmingham, Birmingham, AL, 1977, Nursing
RESEARCH INTERESTSDr. Floyd has a general interest in protein turnover mediated by the ubiquitin-proteasome system. In particular, she is interested in understanding how the ubiquitin-proteasome pathway affects adipose tissue biology. Her research is currently focused on how ubiquitin and ubiquitin-like modifications regulate the activity of the peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor required for the formation of adipocytes.
SELECTED PUBLICATIONSKilroy SG, Kirk-Ballard H, Carter LE, Floyd ZE. The ubiquitin ligase Siah2 regulates PPARgamma activity in adipocytes. Endocrinology 2012; 153 (3): 1206-1218. PMCID: PMC3281538.
Floyd ZE and Stephens JM. Controlling a master switch of adipocyte development and insulin sensitivity: Covalent modification of PPARgamma. Biochem Biophys Acta 2012; 1822: 1090-1095. PMCID: PMC3355475
Kilroy SG, Burk DH, Floyd ZE. High efficiency siRNA transfection of adipocytes using “reverse transfection”. PLoS One 2009; 4(9) e6940. PMCID: PMC2736387
Kilroy SG, Zhang X, Floyd ZE. PPARgamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal. Obesity 2009; (4): 665-73. PMCID: PMC2585986
Floyd ZE, Stephens JM. Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation. Obes Res. 2004; Jun;12(6):921-8.
Floyd, ZE and Stephens JM. IFN gamma-mediated activation and ubiquitin-proteasome dependent degradation of PPAR gamma in adipocytes. 2002; J. Biol. Chem. 277, 4062-4068. ^ top