EDUCATIONPh.D., Louisiana State University, Baton Rouge, LA, 1997, Biochemistry
B.S.N., University of Alabama at Birmingham, Birmingham, AL, 1977, Nursing
RESEARCH INTERESTSDr. Floyd has a general interest in protein turnover mediated by the ubiquitin-proteasome system. In particular, she is interested in understanding how the ubiquitin-proteasome pathway affects adipose tissue biology. Her research is currently focused on how ubiquitin and ubiquitin-like modifications regulate the activity of the peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear hormone receptor required for the formation and maintenance of adipocytes. Recent studies show that the ubiquitin ligase Siah2 selectively regulates PPARgamma activity in adipose tissue while also acting to control adipose tissue inflammation that occurs with obesity and is linked to obesity-induced insulin resistance.
SELECTED PUBLICATIONSKilroy G, Carter LE, Newman S, Burk DH, Manuel J, Moller A, Bowtell DD, Mynatt RL, Ghosh S, Floyd ZE. The ubiquitin ligase Siah2 regulates obesity-induced adipose tissue inflammation. Obesity 2015; 23: 2223-2232. PMCID: PMC4633373
Kilroy SG, Kirk-Ballard H, Carter LE, Floyd ZE. The ubiquitin ligase Siah2 regulates PPARgamma activity in adipocytes. Endocrinology 2012; 153 (3): 1206-1218. PMCID: PMC3281538.
Floyd ZE and Stephens JM. Controlling a master switch of adipocyte development and insulin sensitivity: Covalent modification of PPARgamma. Biochem Biophys Acta 2012; 1822: 1090-1095. PMCID: PMC3355475
Kilroy SG, Burk DH, Floyd ZE. High efficiency siRNA transfection of adipocytes using “reverse transfection”. PLoS One 2009; 4(9) e6940. PMCID: PMC2736387
Kilroy SG, Zhang X, Floyd ZE. PPARgamma AF-2 domain functions as a component of a ubiquitin-dependent degradation signal. Obesity 2009; (4): 665-73. PMCID: PMC2585986
Floyd ZE, Stephens JM. Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation. Obes Res. 2004; Jun;12(6):921-8.
Floyd, ZE and Stephens JM. IFN gamma-mediated activation and ubiquitin-proteasome dependent degradation of PPAR gamma in adipocytes. 2002; J. Biol. Chem. 277, 4062-4068. ^ top