Education

• 2004 – Advanced Training in Cell Biology, University of California San Diego, San Diego, CA (Mentor: Dr. Ted Ciaraldi)
• 1991 – Postdoctoral Fellowship in Physiology and Metabolism, Washington University School of Medicine, St. Louis, MO (Mentor: Dr. John Holloszy)
• 1987 – Doctor of Philosophy in Human Bioenergetics, Ball State University, Muncie, IN (Mentor: Dr. David Costill)
• 1984 – Master of Science in Exercise Biochemistry, University of Massachusetts, Amherst, MA (Mentor: Dr. Priscilla Clarkson)
• 1980 – Bachelor of Arts, University of Limerick, Castletroy, Ireland

Research Interests

Dr. Kirwan's primary research interest is to investigate the role of insulin resistance as an underlying cause of chronic disease, including obesity, type 2 diabetes, non-alcoholic steatohepatitis, asthma, and chronic kidney failure. His lab employs lifestyle, pharmacological, and surgical interventions to identify key regulatory pathways associated with disease progression, with the goal of identifying novel therapeutic targets capable of altering the treatment and management of chronic conditions.

Selected Publications

1. Zunica ERM, Heintz EC, Dantas WS, Hebert RC, Tanksley M, Beyl RA, Mader EC Jr, Kirwan JP, Axelrod CL, Singh P Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial. Physiol Rep. 2024 Feb;12(3):e15948. doi: 10.14814/phy2.15948.PMID: 38346816
2. Taylor AL, Dubuisson O, Pandey P, Zunica ERM, Vandanmagsar B, Dantas WS, Johnson A, Axelrod CL, Kirwan JP Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster. Aging Cell. 2024 Feb 11:e14107. doi: 10.1111/acel.14107. Online ahead of print. PMID: 38343281
3. Zamiri C, Leiske DL, Hughes PF, Kirwan JP, Der E, Cox E, Warburton R, Goss M, Weiser S, Perez-Brown J, Gopalrathnam G, Liu J, Mehta SB, Shereefa S, Specht S, Aedo SJ, Goldbach P, Jia F, Kuehnle B, Page S, Voeten L, Yi L, Zhu C Best Practices for Microbial Challenge In-use Studies to Evaluate the Microbial Growth Potential of Parenteral Biological Products; Industry and Regulatory Considerations. PDA J Pharm Sci Technol. 2023 Oct 17:pdajpst.2022.012806. doi: 10.5731/pdajpst.2022.012806. Online ahead of print. PMID: 37848203
4. Mey JT, Vandagmansar B, Dantas WS, Belmont KP, Axelrod CL, Kirwan JP. Ketogenic propensity is differentially related to lipid-induced hepatic and peripheral insulin resistance. Acta Physiol (Oxf). 2023 Dec;239(4):e14054. doi: 10.1111/apha.14054. Epub 2023 Oct 16.PMID: 37840478
5. Axelrod CL, Langohr I, Dantas WS, Heintz EC, Vandanmagsar B, Yang S, Zunica ERM, Townsend RL, Albaugh VL, Berthoud HR, Kirwan JP. Weight-independent effects of Roux-en-Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice. Obesity (Silver Spring). 2023 Dec 31(12):2960-2971. doi: 10.1002/oby.23876. Epub 2023 Sep 20.PMID: 37731222
6. Ross RC, Heintz EC, Zunica ERM, Townsend RL, Spence AE, Schauer PR, Kirwan JP, Axelrod CL, Albaugh VL. Bariatric surgery alters mitochondrial function in gut mucosa. Surg Endosc. 2023 Nov;37(11):8810-8817. doi: 10.1007/s00464-023-10351-z. Epub 2023 Aug 24.PMID: 37620650 
7. Mey JT, Karpinski CA, Yang S, Madere JD, Piattoly T, Harper R, Kirwan JP. Factors Influencing Nutritional Intake and Interests in Educational Content of Athletes and Sport Professionals Toward the Development of a Clinician-Supported Mobile App to Combat Relative Energy Deficiency in Sport: Formative Research and a Description of App Functions. JMIR Form Res. 2023 Jul 26;7:e45098. doi: 10.2196/45098.PMID: 37494083 
8. Pandey P, Wall PK, Lopez SR, Dubuisson OS, Zunica ERM, Dantas WS, Kirwan JP, Axelrod CL, Johnson AE. A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila. Res Sq.2023 Jun 2:rs.3.rs-2882949. doi: 10.21203/rs.3.rs-2882949/v1. Preprint. PMID: 37398097 
9. Axelrod CL, Dantas WS, Kirwan JP. Sarcopenic obesity: emerging mechanisms and therapeutic potential. 2023 Sep;146:155639. doi: 10.1016/j.metabol.2023.155639. Epub 2023 Jun 26.PMID: 37380015
10. Horwitz LI, Thaweethai T, Brosnahan SB, Cicek MS, Fitzgerald ML, Goldman JD, Hess R, Hodder SL, Jacoby VL, Jordan MR, Krishnan JA, Laiyemo AO, Metz TD, Nichols L, Patzer RE, Sekar A, Singer NG, Stiles LE, Taylor BS, Ahmed S, Algren HA, Anglin K, Aponte-Soto L, Ashktorab H, Bassett IV, Bedi B, Bhadelia N, Bime C, Bind MC, Black LJ, Blomkalns AL, Brim H, Castro M, Chan J, Charney AW, Chen BK, Chen LQ, Chen P, Chestek D, Chibnik LB, Chow DC, Chu HY, Clifton RG, Collins S, Costantine MM, Cribbs SK, Deeks SG, Dickinson JD, Donohue SE, Durstenfeld MS, Emery IF, Erlandson KM, Facelli JC, Farah-Abraham R, Finn AV, Fischer MS, Flaherman VJ, Fleurimont J, Fonseca V, Gallagher EJ, Gander JC, Gennaro ML, Gibson KS, Go M, Goodman SN, Granger JP, Greenway FL, Hafner JW, Han JE, Harkins MS, Hauser KSP, Heath JR, Hernandez CR, Ho O, Hoffman MK, Hoover SE, Horowitz CR, Hsu H, Hsue PY, Hughes BL, Jagannathan P, James JA, John J, Jolley S, Judd SE, Juskowich JJ, Kanjilal DG, Karlson EW, Katz SD, Kelly JD, Kelly SW, Kim AY, Kirwan JP, Knox KS, Kumar A, Lamendola-Essel MF, Lanca M, Lee-Lannotti JK, Lefebvre RC, Levy BD, Lin JY, Logarbo BP Jr, Logue JK, Longo MT, Luciano CA, Lutrick K, Malakooti…See abstract for full author list ➔ Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PLoS One. 2023 Jun 23;18(6):e0286297. doi: 10.1371/journal.pone.0286297. eCollection 2023.PMID: 37352211
11. Thaweethai T, Jolley SE, Karlson EW, Levitan EB, Levy B, McComsey GA, McCorkell L, Nadkarni GN, Parthasarathy S, Singh U, Walker TA, Selvaggi CA, Shinnick DJ, Schulte CCM, Atchley-Challenner R, Alba GA, Alicic R, Altman N, Anglin K, Argueta U, Ashktorab H, Baslet G, Bassett IV, Bateman L, Bedi B, Bhattacharyya S, Bind MA, Blomkalns AL, Bonilla H, Bush PA, Castro M, Chan J, Charney AW, Chen P, Chibnik LB, Chu HY, Clifton RG, Costantine MM, Cribbs SK, Davila Nieves SI, Deeks SG, Duven A, Emery IF, Erdmann N, Erlandson KM, Ernst KC, Farah-Abraham R, Farner CE, Feuerriegel EM, Fleurimont J, Fonseca V, Franko N, Gainer V, Gander JC, Gardner EM, Geng LN, Gibson KS, Go M, Goldman JD, Grebe H, Greenway FL, Habli M, Hafner J, Han JE, Hanson KA, Heath J, Hernandez C, Hess R, Hodder SL, Hoffman MK, Hoover SE, Huang B, Hughes BL, Jagannathan P, John J, Jordan MR, Katz SD, Kaufman ES, Kelly JD, Kelly SW, Kemp MM, Kirwan JP, Klein JD, Knox KS, Krishnan JA, Kumar A, Laiyemo AO, Lambert AA, Lanca M, Lee-Iannotti JK, Logarbo BP, Longo MT, Luciano CA, Lutrick K, Maley JH, Marathe JG, Marconi V, Marshall GD, Martin CF, Matusov Y, Mehari A, Mendez-Figueroa H, Mermelstein R, Metz TD, Morse R, M…See abstract for full author list ➔Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. JAMA. 2023 Jun 13;329(22):1934-1946. doi: 10.1001/jama.2023.8823.PMID: 37278994 
12. Zhang H, Mulya A, Nieuwoudt S, Vandanmagsar B, McDowell R, Heintz EC, Zunica ERM, Collier JJ, Bozadjieva-Kramer N, Seeley RJ, Axelrod CL, Kirwan JP. GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion. Diabetes. 2023 Aug 1;72(8):1070-1082. doi: 10.2337/db22-0019.PMID: 37224335 
13. Beierle J, Algorri M, Cortés M, Cauchon NS, Lennard A, Kirwan JP, Oghamian S, Abernathy MJ. Structured content and data management-enhancing acceleration in drug development through efficiency in data exchange. AAPS Open. 2023;9(1):11. doi: 10.1186/s41120-023-00077-6. Epub 2023 May 8.PMID: 37193559
14. Pandey P, Wall PK, Lopez SR, Dubuisson OS, Zunica ERM, Dantas WS, Kirwan JP, Axelrod CL, Johnson AE. A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila. 2023 Apr 26:2023.04.25.538137. doi: 10.1101/2023.04.25.538137. Preprint.PMID: 37163058 .
15. Rebello CJ, Boué S, Levy RJ Jr, Puyau R, Beyl RA, Greenway FL, Heiman ML, Keller JN, Reynolds CF 3rd, Kirwan JP. Safety and Tolerability of Whole Soybean Products: A Dose-Escalating Clinical Trial in Older Adults with Obesity. Nutrients. 2023 Apr 16;15(8):1920. doi: 10.3390/nu15081920.PMID: 37111139 
16. Mey JT, Kirwan JP, Axelrod CL. The Role of Nutrition in Mitigating the Effects of COVID-19 from Infection through PASC. Nutrients. 2023 Feb 8;15(4):866. doi: 10.3390/nu15040866.PMID: 36839224 Review.
17. Rebello CJ, Zhang D, Kirwan JP, Lowe AC, Emerson CJ, Kracht CL, Steib LC, Greenway FL, Johnson WD, Brown JC Effect of exercise training on insulin-stimulated glucose disposal: a systematic review and meta-analysis of randomized controlled trials. Int J Obes (Lond). 2023 May;47(5):348-357. doi: 10.1038/s41366-023-01283-8. Epub 2023 Feb 24.PMID: 36828899 Review.
18. Kirwan JP, Heintz EC, Rebello CJ, Axelrod CL. Exercise in the Prevention and Treatment of Type 2 Diabetes.Compr Physiol. 2023 Feb 23;13(1):4559-4585. doi: 10.1002/cphy.c220009.PMID: 36815623 Review.
19. Katzmarzyk PT, Myers CA, Nelson MR, Denstel KD, Mire EF, Newton RL Jr, Broyles ST, Kirwan JP Exploring barriers to SARS-CoV-2 testing uptake in underserved black communities in Louisiana. Am J Hum Biol. 2023 Jul;35(7):e23879. doi: 10.1002/ajhb.23879. Epub 2023 Feb 20.PMID: 36807397
20. Albaugh VL, Axelrod C, Belmont KP, Kirwan JP. Physiology Reconfigured: How Does Bariatric Surgery Lead to Diabetes Remission? Endocrinol Metab Clin North Am. 2023 Mar;52(1):49-64. doi: 10.1016/j.ecl.2022.06.003. Epub 2022 Nov 14.PMID: 36754497 Review.
21. Merege-Filho CAA, Gil SS, Kirwan JP, Murai IH, Dantas WS, Nucci MP, Pastorello B, de Lima AP, Bazán PR, Pereira RMR, de Sá-Pinto AL, Lima FR, Brucki SMD, de Cleva R, Santo MA, Leite CDC, Otaduy MCG, Roschel H, Gualano B Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial. Int J Obes (Lond). 2023 Mar;47(3):165-174. doi: 10.1038/s41366-022-01251-8. Epub 2022 Dec 30.PMID: 36585494 
22. Zunica ERM, Axelrod CL, Kirwan JP Phytochemical Targeting of Mitochondria for Breast Cancer Chemoprevention, Therapy, and Sensitization. Int J Mol Sci. 2022 Nov 16;23(22):14152. doi: 10.3390/ijms232214152.PMID: 36430632 Review.
23. Rebello CJ, Beyl RA, Greenway FL, Atteberry KC, Hoddy KK, Kirwan JP Low-Energy Dense Potato- and Bean-Based Diets Reduce Body Weight and Insulin Resistance: A Randomized, Feeding, Equivalence Trial. J Med Food. 2022 Dec;25(12):1155-1163. doi: 10.1089/jmf.2022.0072. Epub 2022 Nov 11.PMID: 36367708
24. Zunica ERM, Heintz EC, Axelrod CL, Kirwan JP. Obesity Management in the Primary Prevention of Hepatocellular Carcinoma. Cancers (Basel). 2022 Aug 22;14(16):4051. doi: 10.3390/cancers14164051.PMID: 36011044  Review.
25. Queiroz AL, Dantas E, Ramsamooj S, Murthy A, Ahmed M, Zunica ERM, Liang RJ, Murphy J, Holman CD, Bare CJ, Ghahramani G, Wu Z, Cohen DE, Kirwan JP, Cantley LC, Axelrod CL, Goncalves MD. Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nat Commun. 2022 Aug 8;13(1):4633. doi: 10.1038/s41467-022-32135-0.PMID: 35941104
26. Kirwan JP, Courcoulas AP, Cummings DE, Goldfine AB, Kashyap SR, Simonson DC, Arterburn DE, Gourash WF, Vernon AH, Jakicic JM, Patti ME, Wolski K, Schauer PR Diabetes Remission in the Alliance of Randomized Trials of Medicine Versus Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D). Diabetes Care.2022 Jul 7;45(7):1574-1583. doi: 10.2337/dc21-2441.PMID: 35320365
27. Scherer PE, Kirwan JP, Rosen CJ Post-acute sequelae of COVID-19: A metabolic perspective. Elife. 2022 Mar 23;11:e78200. doi: 10.7554/eLife.78200.PMID: 35318939 
28. Dantas WS, Zunica ERM, Heintz EC, Vandanmagsar B, Floyd ZE, Yu Y, Fujioka H, Hoppel CL, Belmont KP, Axelrod CL, Kirwan JP Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1821-1836. doi: 10.1002/jcsm.12982. Epub 2022 Mar 19.PMID: 35304976
29. Simonson DC, Hu B, Arterburn DE, Schauer PR, Kashyap SR, Courcoulas AP, Cummings DE, Patti ME, Gourash WF, Vernon AH, Jakicic JM, Kirwan JP. Alliance of Randomized Trials of Medicine vs Metabolic Surgery in Type 2 Diabetes (ARMMS-T2D): Study rationale, design, and methods. Diabetes Obes Metab. 2022 Jul;24(7):1206-1215. doi: 10.1111/dom.14680. Epub 2022 Mar 16.PMID: 35233923
30. Kanaley JA, Colberg SR, Corcoran MH, Malin SK, Rodriguez NR, Crespo CJ, Kirwan JP, Zierath JRExercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Med Sci Sports Exerc. 2022 Feb 1;54(2):353-368. doi: 10.1249/MSS.0000000000002800.PMID: 35029593
31. Rebello CJ, Axelrod CL, Reynolds CF 3rd, Greenway FL, Kirwan JP. Exercise as a Moderator of Persistent Neuroendocrine Symptoms of COVID-19. Exerc Sport Sci Rev. 2022 Apr 1;50(2):65-72. doi: 10.1249/JES.0000000000000284.PMID: 35019862
32. Georas SN, Wright RJ, Ivanova A, Israel E, LaVange LM, Akuthota P, Carr TF, Denlinger LC, Fajt ML, Kumar R, O'Neal WK, Phipatanakul W, Szefler SJ, Aronica MA, Bacharier LB, Burbank AJ, Castro M, Crotty Alexander L, Bamdad J, Cardet JC, Comhair SAA, Covar RA, DiMango EA, Erwin K, Erzurum SC, Fahy JV, Gaffin JM, Gaston B, Gerald LB, Hoffman EA, Holguin F, Jackson DJ, James J, Jarjour NN, Kenyon NJ, Khatri S, Kirwan JP, Kraft M, Krishnan JA, Liu AH, Liu MC, Marquis MA, Martinez F, Mey J, Moore WC, Moy JN, Ortega VE, Peden DB, Pennington E, Peters MC, Ross K, Sanchez M, Smith LJ, Sorkness RL, Wechsler ME, Wenzel SE, White SR, Zein J, Zeki AA, Noel P; PrecISE Study Team The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions. J Allergy Clin Immunol. 2022 Feb;149(2):488-516.e9. doi: 10.1016/j.jaci.2021.10.035. Epub 2021 Nov 29.PMID: 34848210  Review.
33. Hoddy KK, Axelrod CL, Mey JT, Hari A, Beyl RA, Blair JB, Dantas WS, Kirwan JP Insulin resistance persists despite a metabolically healthy obesity phenotype. Obesity (Silver Spring). 2022 Jan;30(1):39-44. doi: 10.1002/oby.23312. Epub 2021 Nov 24.PMID: 34816598
34. Mey JT, Godin JP, Scelsi AR, Kullman EL, Malin SK, Yang S, Floyd ZE, Poulev A, Fielding RA, Ross AB, Kirwan JP. A Whole-Grain Diet Increases Whole-Body Protein Balance Compared with a Macronutrient-Matched Refined-Grain Diet. Curr Dev Nutr. 2021 Sep 25;5(11):nzab121. doi: 10.1093/cdn/nzab121. eCollection 2021 Nov. PMID: 34805723
35. McDowell RE, Ali KF, Lad S, San Martin VT, Bottino R, Walsh M, Stevens T, Wilke W, Kirwan JP, Hatipoglu B. Bioenergetics of Islet Preparations in a Pilot Clinical Trial of Peri-Transplant Hydroxychloroquine for Autologous Islet Transplantation. Cell Transplant. 2021 Jan-Dec;30:9636897211057440. doi: 10.1177/09636897211057440.PMID: 34757864
36. Gil S, Kirwan JP, Murai IH, Dantas WS, Merege-Filho CAA, Ghosh S, Shinjo SK, Pereira RMR, Teodoro WR, Felau SM, Benatti FB, de Sá-Pinto AL, Lima F, de Cleva R, Santo MA, Gualano B, Roschel H.A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery. J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1440-1455. doi: 10.1002/jcsm.12815. Epub 2021 Oct 19.PMID: 34666419
37. Mey JT, Rath MC, McLaughlin K, Galang M, Lynch K, DiMattio J, Nason H, Yang S, Melillo CA, Grove DE, Tonelli AR, Heresi GA, Kirwan JP, Dweik RA. The breath print represents a novel biomarker of malnutrition in pulmonary arterial hypertension: A proof of concept study. JPEN J Parenter Enteral Nutr. 2021 Nov;45(8):1645-1652. doi: 10.1002/jpen.2277. Epub 2021 Nov 12.PMID: 34633675 
38. Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP. Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15.Cancer Metab. 2021 Oct 9;9(1):36. doi: 10.1186/s40170-021-00274-5.PMID: 34627389
39. Zunica ERM, Yang S, Coulter A, White C, Kirwan JP, Gilmore LA. Moringa Oleifera Seed Extract Concomitantly Supplemented with Chemotherapy Worsens Tumor Progression in Mice with Triple Negative Breast Cancer and Obesity. Nutrients. 2021 Aug 24;13(9):2923. doi: 10.3390/nu13092923.PMID: 34578801 
40. King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem. 2021 Oct;297(4):101196. doi: 10.1016/j.jbc.2021.101196. Epub 2021 Sep 13.PMID: 34529976 
41. Zunica ERM, Axelrod CL, Gilmore LA, Kirwan JP. Analytical Determination of Mitochondrial Function of Excised Solid Tumor Homogenates. J Vis Exp. 2021 Aug 6;(174). doi: 10.3791/62875.PMID: 34424252
42. Gil S, Goessler K, Dantas WS, Murai IH, Merege-Filho CAA, Pereira RMR, de Cleva R, Santo MA, Kirwan JP, Roschel H, Gualano B Constraints of Weight Loss as a Marker of Bariatric Surgery Success: An Exploratory Study. Front Physiol. 2021 Jun 11;12:640191. doi: 10.3389/fphys.2021.640191. eCollection 2021.PMID: 34177607
43. Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AECRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech. 2021 Jul 1;14(7):dmm048603. doi: 10.1242/dmm.048603. Epub 2021 Jul 12.PMID: 34160014
44. Aminian A, Kashyap SR, Wolski KE, Brethauer SA, Kirwan JP, Nissen SE, Bhatt DL, Schauer PR. Patient-reported Outcomes After Metabolic Surgery Versus Medical Therapy for Diabetes: Insights From the STAMPEDE Randomized Trial. Ann Surg. 2021 Sep 1;274(3):524-532. doi: 10.1097/SLA.0000000000005003.PMID: 34132694
45. Gualano B, Kirwan JP, Roschel H. Exercise Is Key to Sustaining Metabolic Gains After Bariatric Surgery. Exerc Sport Sci Rev. 2021 Jul 1;49(3):197-204. doi: 10.1249/JES.0000000000000253.PMID: 34112745  Review.
46. Axelrod CL, Fealy CE, Erickson ML, Davuluri G, Fujioka H, Dantas WS, Huang E, Pergola K, Mey JT, King WT, Mulya A, Hsia D, Burguera B, Tandler B, Hoppel CL, Kirwan JP. Lipids activate skeletal muscle mitochondrial fission and quality control networks to induce insulin resistance in humans. 2021 Aug;121:154803. doi: 10.1016/j.metabol.2021.154803. Epub 2021 Jun 4.PMID: 34090870
47. Dantas WS, Roschel H, Murai IH, Gil S, Davuluri G, Axelrod CL, Ghosh S, Newman SS, Zhang H, Shinjo SK, das Neves W, Merege-Filho C, Teodoro WR, Capelozzi VL, Pereira RM, Benatti FB, de Sá-Pinto AL, de Cleva R, Santo MA, Kirwan JP, Gualano B Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes 2020;69:1675-1691. Diabetes. 2021 Jun;70(6):1415. doi: 10.2337/db21-er06b. Epub 2021 May 11.PMID:
48. Kirwan JP, Axelrod CL, Kullman EL, Malin SK, Dantas WS, Pergola K, Del Rincon JP, Brethauer SA, Kashyap SR, Schauer PR. Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults With Type 2 Diabetes. J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4192-e4201. doi: 10.1210/clinem/dgab255.PMID: 33870426
49. Mey JT, Matuska B, Peterson L, Wyszynski P, Koo M, Sharp J, Pennington E, McCarroll S, Micklewright S, Zhang P, Aronica M, Hoddy KK, Champagne CM, Heymsfield SB, Comhair SAA, Kirwan JP, Erzurum SC, Mulya A. Resting Energy Expenditure Is Elevated in Asthma. 2021 Mar 25;13(4):1065. doi: 10.3390/nu13041065.PMID: 33805960 
50. Mosinski JD, Aminian A, Axelrod CL, Batayyah E, Romero-Talamas H, Daigle C, Mulya A, Scelsi A, Schauer PR, Brethauer SA, Kirwan JP Roux-en-Y gastric bypass restores islet function and morphology independent of body weight in ZDF rats. Am J Physiol Endocrinol Metab. 2021 Feb 1;320(2):E392-E398. doi: 10.1152/ajpendo.00467.2020. Epub 2021 Jan 11.PMID: 33427046
51. Hoddy KK, Potts KS, Bazzano LA, Kirwan JP Sleep Extension: A Potential Target for Obesity Treatment. Curr Diab Rep. 2020 Dec 4;20(12):81. doi: 10.1007/s11892-020-01360-6.PMID: 33275183  Review.
52. Gil S, Peçanha T, Dantas WS, Murai IH, Merege-Filho CAA, de Sá-Pinto AL, Pereira RMR, de Cleva R, Santo MA, Rezende DAN, Kirwan JP, Gualano B, Roschel H Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function. Obes Surg. 2021 Mar;31(3):1381-1386. doi: 10.1007/s11695-020-05053-7. Epub 2020 Oct 27.PMID: 33111247 
53. Goessler KF, Nicoletti CF, Rezende DAN, Sieczkowska SM, Esteves GP, Genario R, de Oliveira Júnior GN, Meireles K, Pinto AJ, Nakahara-Melo M, de Cleva R, Santo MA, Kirwan JP, Roschel H, Gualano B. Outpatient Screening of Health Status Among Postbariatric Patients during the COVID-19 Pandemic in Sao Paulo, Brazil.Obesity (Silver Spring). 2020 Dec;28(12):2263-2264. doi: 10.1002/oby.23030. Epub 2020 Oct 21.PMID: 32881292 
54. Navaneethan SD, Kirwan JP, Remer EM, Schneider E, Addeman B, Arrigain S, Horwitz E, Fink JC, Lash JP, McKenzie CA, Rahman M, Rao PS, Schold JD, Shafi T, Taliercio JJ, Townsend RR, Feldman HI; CRIC Study Investigators. Adiposity, Physical Function, and Their Associations With Insulin Resistance, Inflammation, and Adipokines in CKD. Am J Kidney Dis. 2021 Jan;77(1):44-55. doi: 10.1053/j.ajkd.2020.05.028. Epub 2020 Aug 13.PMID: 32798563 
55. Rebello CJ, Kirwan JP, Greenway FL.Obesity, the most common comorbidity in SARS-CoV-2: is leptin the link?Int J Obes (Lond). 2020 Sep;44(9):1810-1817. doi: 10.1038/s41366-020-0640-5. Epub 2020 Jul 9.PMID: 32647360  Review.
56. Lai N, Fealy CE, Kummitha CM, Cabras S, Kirwan JP, Hoppel CL.Mitochondrial Utilization of Competing Fuels Is Altered in Insulin Resistant Skeletal Muscle of Non-obese Rats (Goto-Kakizaki). Front Physiol. 2020 Jun 16;11:677. doi: 10.3389/fphys.2020.00677. eCollection 2020.PMID: 32612543 
57. Vangoitsenhoven R, Wilson R, Sharma G, Punchai S, Corcelles R, Froylich D, Mulya A, Schauer PR, Brethauer SA, Kirwan JP, Sangwan N, Brown JM, Aminian A. Metabolic effects of duodenojejunal bypass surgery in a rat model of type 1 diabetes. Surg Endosc. 2021 Jun;35(6):3104-3114. doi: 10.1007/s00464-020-07741-y. Epub 2020 Jun 30.PMID: 32607903
58. Malin SK, Navaneethan SD, Fealy CE, Scelsi A, Huang H, Rocco M, Kirwan JP. Exercise plus caloric restriction lowers soluble RAGE in adults with chronic kidney disease. Obes Sci Pract. 2020 Feb 11;6(3):307-312. doi: 10.1002/osp4.408. eCollection 2020 Jun.PMID: 32523720
59. Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med. 2020 Jul 7;12(7):e12088. doi: 10.15252/emmm.202012088. Epub 2020 Jun 10.PMID: 32519812 
60. Vangoitsenhoven R, Mulya A, Mosinski JD, Brethauer SA, Schauer PR, Kirwan JP, Aminian A Effects of gastric bypass surgery on expression of glucose transporters and fibrotic biomarkers in kidney of diabetic fatty rats.Surg Obes Relat Dis. 2020 Sep;16(9):1242-1248. doi: 10.1016/j.soard.2020.04.017. Epub 2020 Apr 24.PMID: 32505735
61. Erickson ML, Zhang H, Mey JT, Kirwan JP Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes. Med Sci Sports Exerc. 2020 Oct;52(10):2078-2085. doi: 10.1249/MSS.0000000000002368.PMID: 32496736
62. Dantas WS, Roschel H, Murai IH, Gil S, Davuluri G, Axelrod CL, Ghosh S, Newman SS, Zhang H, Shinjo SK, das Neves W, Merege-Filho C, Teodoro WR, Capelozzi VL, Pereira RM, Benatti FB, de Sá-Pinto AL, de Cleva R, Santo MA, Kirwan JP, Gualano B. Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes. 2020 Aug;69(8):1675-1691. doi: 10.2337/db19-1180. Epub 2020 May 14.PMID: 32409493
63. Mey JT, Erickson ML, Axelrod CL, King WT, Flask CA, McCullough AJ, Kirwan JP β-Hydroxybutyrate is reduced in humans with obesity-related NAFLD and displays a dose-dependent effect on skeletal muscle mitochondrial respiration in vitro. Am J Physiol Endocrinol Metab. 2020 Jul 1;319(1):E187-E195. doi: 10.1152/ajpendo.00058.2020. Epub 2020 May 12.PMID: 32396388
64. Erickson ML, Mey JT, Axelrod CL, Paul D, Gordesky L, Russell K, Barkoukis H, O'Tierney-Ginn P, Fielding RA, Kirwan JP, Catalano PM. Rationale and study design for lifestyle intervention in preparation for pregnancy (LIPP): A randomized controlled trial. Contemp Clin Trials. 2020 Jul;94:106024. doi: 10.1016/j.cct.2020.106024. Epub 2020 May 8.PMID: 32389808
65. Rubino F, Puhl RM, Cummings DE, Eckel RH, Ryan DH, Mechanick JI, Nadglowski J, Ramos Salas X, Schauer PR, Twenefour D, Apovian CM, Aronne LJ, Batterham RL, Berthoud HR, Boza C, Busetto L, Dicker D, De Groot M, Eisenberg D, Flint SW, Huang TT, Kaplan LM, Kirwan JP, Korner J, Kyle TK, Laferrère B, le Roux CW, McIver L, Mingrone G, Nece P, Reid TJ, Rogers AM, Rosenbaum M, Seeley RJ, Torres AJ, Dixon JB. Joint international consensus statement for ending stigma of obesity. Nat Med. 2020 Apr;26(4):485-497. doi: 10.1038/s41591-020-0803-x. Epub 2020 Mar 4. PMID: 32127716  Review.
66. Heresi GA, Mey JT, Bartholomew JR, Haddadin IS, Tonelli AR, Dweik RA, Kirwan JP, Kalhan SC Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension.
67. Pulm Circ. 2020 Feb 4;10(1):2045894019890553. doi: 10.1177/2045894019890553. eCollection 2020 Jan-Mar. PMID: 32110382 
68. Mey JT, Hari A, Axelrod CL, Fealy CE, Erickson ML, Kirwan JP, Dweik RA, Heresi GA. Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study. Eur Respir J. 2020 Apr 9;55(4):1901700. doi: 10.1183/13993003.01700-2019. Print 2020 Apr. PMID: 32108049
69. Pinto AJ, Peçanha T, Meireles K, Benatti FB, Bonfiglioli K, de Sá Pinto AL, Lima FR, Pereira RMR, Irigoyen MCC, Turner JE, Kirwan JP, Owen N, Dunstan DW, Roschel H, Gualano B. A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study.Trials. 2020 Feb 12;21(1):171. doi: 10.1186/s13063-020-4104-y.PMID: 32051025
70. Hari A, Fealy CE, Axelrod CL, Haus JM, Flask CA, McCullough AJ, Kirwan JP Exercise Training Rapidly Increases Hepatic Insulin Extraction in NAFLD. Med Sci Sports Exerc. 2020 Jul;52(7):1449-1455. doi: 10.1249/MSS.0000000000002273.PMID: 32028458
71. Axelrod CL, Brennan CJ, Cresci G, Paul D, Hull M, Fealy CE, Kirwan JP UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans. Physiol Rep. 2019 Nov;7(22):e14276. doi: 10.14814/phy2.14276.PMID: 31758610
72. Nock NL, Dimitropoulos A, Zanotti KM, Waggoner S, Nagel C, Golubic M, Michener CM, Kirwan JP, Alberts J Sleep, quality of life, and depression in endometrial cancer survivors with obesity seeking weight loss. Support Care Cancer. 2020 May;28(5):2311-2319. doi: 10.1007/s00520-019-05051-1. Epub 2019 Sep 2. PMID:  31478164