Education
- Postdoctoral Fellow, Military Nutrition Division, US Army Research Institute of Environmental Medicine, 2018
- PhD, Nutritional Sciences, Penn State University, Department of Nutritional Sciences, 2014
- MS, Nutritional Sciences, University of New Hampshire, Department of Molecular, Cellular, and Biomedical Sciences, 2010
- BS, Nutritional Sciences, University of New Hampshire, Department of Molecular, Cellular, and Biomedical Sciences, 2008
Research Interests
The Micronutrient Metabolism Lab investigates strategies to improve micronutrient status in vulnerable populations. Current projects focus on the impacts of food deprivation and infection on iron requirements and novel iron supplementation strategies to correct iron deficiency in children and women of reproductive age.
Selected Publications
- Miller KM, Reddy MB, Quashie D, Velez FJ, Ali J, Singh P, Hennigar SR. Iron-enriched Aspergillus oryzae as an alternative to iron sulfate to limit iron accumulation, growth, and motility of the enteric pathogen S. Typhimurium. Br J Nutr, 2022, in press.
- Murphy RD, James KM, Ippolito JR, Barney DE, Miller KM, Murphy NE, Gwin JA, Pasiakos, SM, McClung JP, Margolis LM, Hennigar SR. Mild to moderate food deprivation increases hepcidin and results in hypoferremia and tissue iron sequestration in mice. J Nutr, 152:2198-2208, 2022.
- Barney DE, Ippolito JR, Berryman CE, Hennigar SR. A prolonged bout of running increases hepcidin and decreases dietary iron absorption in trained female and male runners. J Nutr, 152:2013-2014, 2022. 152:2039-2047, 2022.
- Ippolito JR, Piccolo BD, Robeson MS, Barney DE, Ali J, Singh P, Hennigar SR. Iron deficient diets modify the gut microbiome and reduce the severity of enteric infection in a mouse model of S. Typhimurium-induced enterocolitis. J Nutr Biochem, 107:109065, 2022.
- Hennigar SR, Olson CI, Kelley AM, McClung JP. Slc39a4 in the small intestine predicts zinc absorption and utilization: a comprehensive analysis of zinc transporter expression in response to diets of varied zinc content in young mice. J Nutr Biochem, 101: 108927, 2022.
- Hennigar SR, McClung JP, Hatch-McChesney A, Allen JT, Wilson MA, Carrigan CT, Murphy NE, Teien HK, Martini S, Gwin JA, Karl JP, Margolis LM, Pasiakos SM. Energy deficit increases hepcidin and exacerbates declines in dietary iron absorption following strenuous physical activity: a randomized-controlled cross-over trial. Am J Clin Nutr, 113:359-369, 2022.
- Hennigar SR, Kelley AM, Anderson BJ, Armstrong NJ, McClung HL, Berryman CE, Karl JP, McClung JP. Sensitivity and reliability of zinc transporter and metallothionein gene expression in peripheral blood mononuclear cells as indicators of zinc status: responses to ex vivo zinc exposure and habitual zinc intake in humans. Br J Nutr, 125:361-368, 2021.
- Hennigar SR, Berryman CE, Kelley AM, Anderson BJ, Young AJ, McClung JP, Pasiakos SM. High-altitude acclimatization suppresses hepcidin expression during severe energy deficit. High Alt Med Biol, 21:232-236, 2020.
- Hennigar SR, Berryman CE, Harris MN, Karl JP, Lieberman HR, McClung JP, Rood JC, Pasiakos SM. Testosterone Administration During Energy Deficit Suppresses Hepcidin and Increases Iron Availability for Erythropoiesis. J Clin Endocrinol Metab, 105:dgz316, 2020.
- Hennigar SR, Lieberman HR, Fulgoni VL, McClung JP. Serum zinc concentrations in the US population are related to sex, age, and time of blood draw but not dietary or supplemental zinc. J Nutr, 148:1341-1351, 2018.
- Hennigar SR, McClung JP. Hepcidin attenuates zinc efflux in Caco-2 cells. 146:2167-2173, 2016.
