Sangho Yu, 

Assistant Professor - Research


(225) 763-2808
(225) 763-0260
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B.S., 2003, Yonsei University, Seoul, South Korea
Ph.D., 2009, UT Southwestern Medical Center, Dallas, TX


Total energy expenditure is crucially regulated by central thermoregulatory pathways that receive nutritional, hormonal, and environmental signals to determine the overall sympathetic output to various effector organs. Thus, thermoregulation is an essential component for energy homeostasis and body weight regulation. My research focuses on following areas using various transgenic mouse models combined with highly sophisticated viral tools, such as chemogenetics and optogenetics:

1) Thermoregulatory circuits and mechanisms mediated by leptin receptor (LepRb) neurons in the preoptic area (POA).
2) Identification of novel genes and neuronal populations involved in energy homeostasis.
3) Neural substrates and mechanisms controlling energy balance.


Yu S, Qualls-Creekmore E, Rezai-Zadeh K, Jiang Y, Berthoud HR, Morrison CD, Derbenev AV, Zsombok A, Münzberg H. Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci. 2016 May 4;36(18):5034-46. doi: 10.1523/JNEUROSCI.0213-16.2016. PubMed PMID: 27147656; PubMed Central PMCID: PMC4854966.

Münzberg H, Qualls-Creekmore E, Yu S, Morrison CD, Berthoud HR. Hedonics Act in Unison with the Homeostatic System to Unconsciously Control Body Weight. Front Nutr. 2016 Feb 15;3:6. doi: 10.3389/fnut.2016.00006. eCollection 2016. Review. PubMed PMID: 26913284; PubMed Central PMCID: PMC4753312.

Münzberg H, Qualls-Creekmore E, Berthoud HR, Morrison CD, Yu S. Neural Control of Energy Expenditure. Handb Exp Pharmacol. 2016;233:173-94. doi: 10.1007/164_2015_33. PubMed PMID: 26578523; PubMed Central PMCID: PMC4818114.

Laque A, Yu S, Qualls-Creekmore E, Gettys S, Schwartzenburg C, Bui K, Rhodes C, Berthoud HR, Morrison CD, Richards BK, Münzberg H. Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons. Mol Metab. 2015 Jul 16;4(10):706-17. doi: 10.1016/j.molmet.2015.07.002. eCollection 2015 Oct. PubMed PMID: 26500842; PubMed Central PMCID: PMC4588437.

Münzberg H, Laque A, Yu S, Rezai-Zadeh K, Berthoud HR. Appetite and body weight regulation after bariatric surgery. Obes Rev. 2015 Feb;16 Suppl 1:77-90. doi: 10.1111/obr.12258. Review. PubMed PMID: 25614206; PubMed Central PMCID: PMC4784979.

Rezai-Zadeh K, Yu S, Jiang Y, Laque A, Schwartzenburg C, Morrison CD, Derbenev AV, Zsombok A, Münzberg H. Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake. Mol Metab. 2014 Aug 6;3(7):681-93. doi: 10.1016/j.molmet.2014.07.008. eCollection 2014 Oct. PubMed PMID: 25352997; PubMed Central PMCID: PMC4209380. ^ top