Sangho Yu, 

Assistant Professor - Research


(225) 763-2808
(225) 763-0260
Send E-mail 


B.S., 2003, Yonsei University, Seoul, South Korea
Ph.D., 2009, UT Southwestern Medical Center, Dallas, TX


Total energy expenditure is crucially regulated by central thermoregulatory pathways that receive nutritional, hormonal, and environmental signals to determine the overall sympathetic output to various effector organs. Thus, thermoregulation is an essential component for energy homeostasis and body weight regulation. My research focuses on following areas using various transgenic mouse models combined with highly sophisticated viral tools, such as chemogenetics and optogenetics:

1) Thermoregulatory circuits and mechanisms mediated by leptin receptor (LepRb) neurons in the preoptic area (POA).
2) Identification of novel genes and neuronal populations involved in energy homeostasis.
3) Neural substrates and mechanisms controlling energy balance.


Yu S, Cheng H, François M, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombok A, Derbenev AV, Nillni EA, Burk DH, Morrison CD, Berthoud HR, Münzberg H. Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife. 2018 May 15;7. pii: e33505. doi: 10.7554/eLife.33505. PubMed PMID: 29761783.

François M, Qualls-Creekmore E, Berthoud HR, Münzberg H, Yu S. Genetics-based manipulation of adipose tissue sympathetic innervation. Physiol Behav. 2018 Jun 1;190:21-27. doi: 10.1016/j.physbeh.2017.08.024. Epub 2017 Aug 30. Review. PubMed PMID: 28859876; PubMed Central PMCID: PMC5832526.

Yu S, François M, Huesing C, Münzberg H. The Hypothalamic Preoptic Area and Body Weight Control. Neuroendocrinology. 2018;106(2):187-194. doi: 10.1159/000479875. Epub 2017 Aug 10. PubMed PMID: 28772276.

Qualls-Creekmore E, Yu S, Francois M, Hoang J, Huesing C, Bruce-Keller A, Burk D, Berthoud HR, Morrison CD, Münzberg H. Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion. J Neurosci. 2017 Jun 21;37(25):6053-6065. doi: 10.1523/JNEUROSCI.0155-17.2017. Epub 2017 May 24. PubMed PMID: 28539422; PubMed Central PMCID: PMC5481941.

Yu S, Qualls-Creekmore E, Rezai-Zadeh K, Jiang Y, Berthoud HR, Morrison CD, Derbenev AV, Zsombok A, Münzberg H. Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci. 2016 May 4;36(18):5034-46. doi: 10.1523/JNEUROSCI.0213-16.2016. PubMed PMID: 27147656; PubMed Central PMCID: PMC4854966. ^ top