Heike Muenzberg-Gruening, Ph.D.

Professor

Department/Laboratory:
Phone:
(225) 763-2769
Fax:
(225) 763-0260
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EDUCATION

Diploma, Phillips University, Marburg, Germany
Ph.D., University Hospital Hamburg and Universtiy Hospital Heidelberg, Germany (Biology)
Postdoctoral Training, Harvard University/BIDMC, Boston, USA

RESEARCH INTERESTS

Dissection of neuronal circuits (CNS and peripheral nervous system) that are involved in the physiological adaptation of energy expenditure and food intake (e.g. temperature and energy sensing).

Integration of exteroceptive and interoceptive signals (e.g. cold, diet, fasting, leptin, norepinephrine) to adapt energy expenditure and food intake in response to physiological challanges.

Role of leptin in the homeostatic regulation of energy expenditure and food intake.

We use a variety of molecular genetic and viral approaches (in vivo chemogenetics, optogenetics, fiber photometry) to dissect central or peripheral neuronal circuits that are involved in energy expenditure and food intake adaptation.

We use whole body and whole spinal cord iDISCO staining and tissue clearing to visualize central (hypothalamic) and peripheral circuits (sympathetic pre- and postganglionic neurons) using light sheet and confocal microscopy of large specimen.

SELECTED PUBLICATIONS

Huesing C, Qualls-Creekmore E, Lee L, Francois M, Torres H, Zhang R, Burk DH, Yu S, Morrison CD, Berthoud HR, Neuhuber W, Münzberg H:Sympathetic innervation of inguinal white adipose tissue in the mouse. J Comp. Neurology 2020 ahead of print

Münzberg H, Singh P, Heymsfield SB, Yu S, Morrison CD: Recent advances in understanding the role of leptin in energy homeostasis. F1000Res. May 27; 9; F1000 Faculty Rev-451 eCollection 2020, PMID:32518627

Francois M, Torres H, Huesing C, Zhang R, Saurage C, Lee N, Qualls-Creemore E, Yu S, Morrison CD, Burk D, Berthoud HR, Münzberg H:Sympathetic innervation of the interscapular brown adipose tissue in the mouse. Ann NY Acad Sci, 2019 Jun 11, PMID:31184376

Yu S, Münzberg H: Testing Effects of Chronic Chemogeneitic Neuronal Stiulation on Energy Balance by Indirect Calorimetry. Bio Protoc., 2018, 8(8):e2811, PMCID:PMC6018017

Yu S, Cheng H, Francois M, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombock A, Derbenev AV, Morrison CD, Berthoud HR, Münzberg H: Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife, 2018, 7:e33505, PMCID:PMC5953538

Francois M, Qualls-Creekmore E, Berthoud HR, Münzberg H, Yu S: Genetics-based manipulation of adipose tissue sympathetic innervation. Physiology & Behavior, 190:21-27, 2017, PMCID:PMC5832526

Yu S, Francois M, Huesing C, Münzberg H: The Hypothalamic Preoptic Area and Body Weight Control. Neuroendocrinology, 2018, 106(2):187-194

Qualls-Creekmore E, Yu S, Francois M, Hoang J, Huesing C, Bruce-Keller A, Berthoud HR, Morrison CD, Münzberg H: Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion. J Neuroscience, 37(25):6053-6065, 2017, PMCID:PMC5481941

Münzberg H, Qualls-Creekmore E, Yu S, Morrison CD, Berthoud H-R: Hedonics Act in Unison with the Homeostatic System to Unconsciously Control Body Weight. Front Nutr. 2016, 15:3-6

Yu S, Rezai-Zadeh K, Jiang Y, Berthoud HR, Morrison CD, Derbenev AV, Zombok A, Münzberg H: Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis. J Neurosci, 2016, 36(18):5034-46, PMCID:PMC4854966

Münzberg H, Qualls-Creekmore E, Berthoud H-R, Morrison CD, Yu S: Neural Control of Energy Expenditure. Handbook Experimental Pharmacology, 2015, Epub

Laque A, Yu S, Qualls-Creekmore E, Gettys S, Schwartzenburg C, Bui K, Rhodes C, Berthoud HR, Morrison CD, Richards BK, Münzberg H: Leptin modulates nutrient reward via inhibitory galanin action on orexin neurons. Molecular Metabolism, 2015, 4(10):706-17, PMCID:PMC4588437

Rezai-Zadeh K, Yu, Sangho, Jiang Y, Laque A, Schwartzenburg C, Morrison CD, Derbenev AV, Zsombok A, Münzberg H: Leptin Receptor Neurons in the Dorsomedial Hypothalamus are Key Regulators of Enenergy Expenditure and body weight, but not Food Intake. Molecular Metabolism 2014,3:681-93, PMCID: PMC4209380, featured on Journal’s title page

Münzberg H, Laque A, Yu S, Rezai-Zadeh, Berthoud H-R: Appetite and body weight regulation after bariatric surgery. Int J Obes, Review, 2015, Suppl 1:77-90

Rezai-Zadeh K, Münzberg H: Integration of sensory information via central thermoregulatory leptin targets. Physiol Behav. 2013, 121:49-55, PMCID: PMC3683124

Laque A, Zhang Y, Gettys S, Nguyen TA, Bui K, Morrison CD, Münzberg H: Leptin receptor neurons in the mouse hypothalamus are co-localized with the neuropeptide galanin and mediate anorexigenic leptin action. AJP Endocrinol Metab, Epub Mar 2013, PMCID:PMC3651648.

Zhang Y, Kerman IA, Laque A, Faouzi M, Louis GW, Jones JC, Rhodes C, Münzberg H: Leptin Receptor Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits. J Neurosci., 31(5):1873-84, 2011, PMCID:PMC3069639.

Berthoud HR, Münzberg H: The lateral hypothalamus as intergrator of metabolic and environmental needs:from electrical self-stimulation to opto-genetics. Physiol Behav., 104(1):29-39, 2011 PMCID:PMC3131619.
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