Thomas Gettys, Ph.D.

John Henry Hernandez Endowed Professorship in Health Promotion
PI, Pennington Center of Biomedical Research Excellence
Professor

Department/Laboratory:

Phone:
(225) 763-3165
 
Fax:
(225) 763-0274
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EDUCATION

Ph.D., Clemson University, Clemson, SC, 1984, Nutrition/Physiology

Postdoctoral Training, Vanderbilt University School of Medicine & Howard Hughes Medical Institute, Nashville, TN, Molecular Physiology

RESEARCH INTERESTS

Dr. Gettys has a broad interest in the signaling systems which link cell surface receptors to transcriptional programs regulating the metabolic and endocrine functions of adipose tissue. An additional area of interest includes the nutrient sensing mechanisms linking modulation of specific subsets of genes by dietary macronutrients, including lipids and amino acids.

SELECTED PUBLICATIONS

Wanders, D., L.A. Forney, Stone, K.P., B.E. Hasek, W. Johnson, and Gettys, T.W. 2018. The components of age-dependent effects of dietary methionine restriction on energy balance in rats. Obesity (Silver Spring) 26: 740-746. PMCID: PMC5866213.

Forney, L.A., Stone, K.P., Wanders, D., and Gettys, T.W. 2017. Sensing and signaling mechanisms linking dietary methionine restriction to the behavioral and physiological components of the response. Frontiers in Neuroendocrinology 51: 36-45. PMCID: PMC6013330

Forney, L.A., Stone, K.P., Wanders, D., Ntambi, J.M., and Gettys, T.W. 2018. The role of suppression of hepatic SCD1 expression in the metabolic effects of dietary methionine restriction. Applied Physiology, Nutrition and Metabolism 43: 123-130. PMCID: PMC5788716.

Ghosh, S., Forney, L.A., Wanders, D., Stone, K.P., and Gettys, T.W. 2017. An integrative analysis of tissue-specific transcriptomic and metabolomic responses to short-term dietary methionine restriction in mice. PLOS One doi.org/10.1371/journal.pone.0177513. PMCID: PMC5433721.

Forney, L.A., Wanders, D., Stone, K.P., Pierse, A., and Gettys, T.W. 2017. Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype. Obesity (Silver Spring) 25: 730-738. PMCID: PMC5373958.

Wanders, D., Forney, L.A., Stone, K.P., Burk, D.H., Pierse, A., and Gettys, T.W. 2017. FGF21 mediates the thermogenic and insulin-sensitizing effects of dietary methionine restriction but not its effects on hepatic lipid metabolism. Diabetes 66: 858-867. PMCID: PMC5360300.

Wanders, D., Stone, K.P., Forney, L.A., Cortez, C.C., Dille, K.N., Simon, J., Xu, M., Hotard, E.C., Nikonorova, I.A., Pettit, A.P., Anthony, T.G., and Gettys, T.W. 2016. Role of GCN2-independent signaling through a non-canonical PERK/NRF2 pathway in the physiological responses to dietary methionine restriction. Diabetes 65: 1499-1510. PMCID:4878423

Stone, K.P., Wanders, D., Calderon, L.F., Spurgin, S.B., Scherer, P.E., and Gettys, T.W. 2015. Compromised responses to dietary methionine restriction in adipose tissue but not liver of ob/ob mice. Obesity (Silver Spring) 23: 1836-1844. PMCID: 4551572

Patil, Y.N., Dille, K.N., Burk, D.H., Cortez, C.C., and Gettys, T.W. 2015. Cellular and molecular remodeling of inguinal adipose tissue by dietary methionine restriction. Journal of Nutritional Biochemistry 26: 1235-1247. PMCID: 4631695.

Wanders, D., Stone, K.P., Dille, K.N., Simon, J., Pierse, A., and Gettys, T.W. 2015. Metabolic responses to dietary leucine retriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling. Biofactors 41: 391-402. PMCID: 4715699.

Wanders, D., Burk, D.H., Cortez, C.C., Van, N.T., Stone, K.P., Baker, M., Mendoza, T., Mynatt, R.L., and Gettys, T.W. 2015. UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity. FASEB J. 29: 2603-2615. PMCID: 4447219

Stone, K.P., Wanders, D., Orgeron, M., Cortez, C. and Gettys, T.W. 2014. Mechanisms of increased in vivo insulin sensitivity by dietary methionine restriction in mice. Diabetes 63: 3721-3733. PMCID: 4207389

Ghosh, S., Wanders, D., Stone, K.P., Van, N.T., Cortez, C.C., and Gettys, T.W. 2014. A systems biology analysis of the unique and overlapping transcriptional responses to calorie restriction and dietary methionine restriction in rats. FASEB J. 28: 2577-2590. PMCID:4021438

Hasek, B.E., Boudreau, A., Shin, J., Feng, D., Laque, A.I., Listi, D., Stewart, L.K., Prufer-Stone, K., Pessin, J., and Gettys, T.W. 2013. Transcriptional remodeling of the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction. Diabetes 62: 3362-3372. PMCID: 3781441.

Anthony, T.G., Morrison, C.D., and Gettys, T.W. 2013. Remodeling of lipid metabolism by dietary restriction of essential amino acids Diabetes 62: 2635-2644. PMCID:3717867 ^ top