Thomas Gettys, Ph.D.

PI, Pennington Center of Biomedical Research Excellence
Professor

Department/Laboratory:
Nutrient Sensing and Adipocyte Signaling
Phone:
(225) 763-3165
 
Fax:
(225) 763-0274
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EDUCATION

Ph.D., Clemson University, Clemson, SC, 1984, Nutrition/Physiology

Postdoctoral Training, Vanderbilt University School of Medicine & Howard Hughes Medical Institute, Nashville, TN, Molecular Physiology

RESEARCH INTERESTS

Dr. Gettys has a broad interest in the signaling systems which link cell surface receptors to transcriptional programs regulating the metabolic and endocrine functions of adipose tissue. An additional area of interest includes the nutrient sensing mechanisms linking modulation of specific subsets of genes by dietary macronutrients, including lipids and amino acids.

SELECTED PUBLICATIONS

Anthony, T.G., Morrison, C.D., and Gettys, T.W. 2013. Remodeling of lipid metabolism by dietary restriction of essential amino acids Diabetes (in press).

Chang, J.S., Fernand, V., Zhang, Y., Joshi, Y., Leonne, T., Kelly, D.P., and Gettys, T.W. 2012. NT-PGC-1a protein is sufficient to link ß3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. Journal of Biological Chemistry 287: 9100-9112.

Plaisance, E.P., Greenway, F.L., Boudreau, A., Hill, K.L., Johnson, W.D., Perrone, C.E., Orentreich, N., Cefalu, W.T., and Gettys, T.W. 2011. Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome. Journal of Clinical Endocrinology & Metabolism 96: E836-840.

Chang, J.S., Huypens, P., Zhang, Y., Black, C., Kralli ,A., and Gettys, T.W. 2010. Regulation of NT-PGC-1a subcellular localization and function by PKA-dependent modulation of nuclear export by CRM1. Journal of Biological Chemistry 285: 18039-18050.

Hasek, B.E., Stewart, L.K., Henagan, T.M., Boudreau, A., Lenard , N., Black, C., Shin, J., Huypens, P., Malloy, V., Plaisance E., Krajcik, R.A., Orentreich, N., and Gettys, T.W. 2010. Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states. American Journal of Physiology 299: R728-739.

Plaisance, E.P., Henagan, T.M., Echlin, H., Boudreau, A., Lenard N.R., Hasek, B.E., Orentreich, N., and Gettys, T.W. 2010. Role of the ß3-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction. American Journal of Physiology 299: R740-750.

Zhang, Y., Huypens, P., Adamson, A.W., Chang, J.S., Henagan, T.M., Boudreau A., Lenard, N.R., Burk, D., Klein, J., Perwitz, N., Shin, J., Fasshauer, M., Kralli, A., and Gettys, T.W. 2009. Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1a Journal of Biological Chemistry 284:32813-32826. ^ top