Pennington Biomedical’s Prachi Singh Secures $3.7 Million Grant to Study Reduced Sleep and Intermittent Fasting

July 31, 2023

The NIH’s National Heart, Lung, and Blood Institute awarded the grant to support Dr. Singh’s research into the cardiovascular risks of limited sleep

For more information, contact Joe Coussan, Joe.coussan@pbrc.edu, 225-763-3049

BATON ROUGE – While we typically wouldn’t give a second thought to that midnight snack, a shortened sleep cycle and the resulting extended eating duration can contribute to higher cardiovascular risk. Dr. Prachi Singh of the Pennington Biomedical Research Center in Baton Rouge has been awarded a $3.7 million grant from the National Institutes of Health’s National Heart, Lung, and Blood Institute to look into this further to pursue the benefits of time-restricted eating for short sleepers.

The grant will be administered over five years, and Dr. Singh plans to use a portion of the funds to add additional staff to her lab. She will ultimately conduct a study to see if changes like intermittent fasting can curb the negative effects of a misaligned circadian rhythm and short sleep duration.

“Shortened sleep duration can result in a wide array of health problems, and with nearly 33 percent of all adults getting less than the recommended amount of sleep, the need to identify and address the roots of these problems is becoming more and more urgent,” said Dr. Singh, who serves as the Director for Pennington Biomedical’s Sleep and Cardiometabolic Health Lab. “This is especially important, as even when we are aware of the negative health consequences of short sleep duration, we find it difficult to develop a routine that consistently includes time for adequate sleep duration.”

Dr. Singh added, “It is an honor to receive this grant from the NIH to study this phenomenon and pursue approaches to curb the negative health effects of limited sleep and extended calorie intake.”

Currently, one out of every three adults in the U.S. reports to sleep six hours or less most nights of the week – a habit that can contribute to high cardiovascular risk and disease. Additionally, habitual short sleepers are more likely to eat at irregular intervals, usually consuming more than daily recommendations – a behavior that further contributes to heightened cardiovascular and metabolic risk.

The circadian system in humans is key to maintaining a balance or homeostasis in the body, but a misalignment of the circadian rhythm, such as a shortened sleep duration, coupled with extended snacking times and duration, can lead to high blood pressure and insulin resistance.

To identify ways to curb the frequency and intensity of some issues, or to potentially reverse them altogether, Dr. Singh will develop a study of participants who are confirmed habitual short sleepers and randomly assign them to habitual eating duration groups of more than 14 hours per day, and those in a time restricted eating group, with only 8 hours of eating per day. To ensure participation, the research team will continuously monitor glucose, sleep duration, physical activity and light exposure.

As the Director of the Sleep and Cardiometabolic Health Lab at Pennington Biomedical, Dr. Singh primarily focuses on the interactions among sleep, nutrition and obesity-related cardiometabolic disorders.

“Dr. Singh is representative of the talented, dedicated researchers here at Pennington Biomedical, and her receipt of the NIH grant is a testament to her research ability and skill,” said Dr. John Kirwan, Executive Director of Pennington Biomedical Research Center. “Our mission to discover the triggers of chronic disease touches on all potential avenues, and Dr. Singh’s lab is taking an innovative approach to studying sleep, nutrition and cardiovascular health.”

About the Pennington Biomedical Research Center

The Pennington Biomedical Research Center is at the forefront of medical discovery as it relates to understanding the triggers of obesity, diabetes, cardiovascular disease, cancer and dementia. The Center architected the national “Obecity, USA” awareness and advocacy campaign to help solve the obesity epidemic by 2040. The Center conducts basic, clinical, and population research, and is affiliated with LSU.

The research enterprise at Pennington Biomedical includes over 480 employees within a network of 40 clinics and research laboratories, and 13 highly specialized core service facilities. Its scientists and physician/scientists are supported by research trainees, lab technicians, nurses, dietitians, and other support personnel. Pennington Biomedical a state-of-the-art research facility on a 222-acre campus in Baton Rouge.

For more information, see www.pbrc.edu.

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