Our Faculty
Donald Ingram, Ph.D.
Professor

Department/Laboratory:
Nutritional Neuroscience and Aging
Animal Metabolism and Behavior Core
Phone:
(225) 763-2594
 		 Fax:
(225) 763-0261
Send E-mail  | View CV 
 
Education:
Louisiana State University, Baton Rouge, LA B.A. 1966-1970 Psychology
University of Georgia, Athens, GA M.S. 1974-1977 Psychology
University of Georgia, Athens, GA Ph.D. 1977-1978 Psych & Gerontology
The Jackson Laboratory, Bar Harbor, ME Post-doc 1978-1980 Behavior Genetics
National Institute on Aging, NIH, Baltimore, MD Staff Fellow 1980-1984 Neurobiology of Aging

Position prior to joining PBRC:

Chief, Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD
Research Interests:

Dr. Ingram’s research has focused on nutritional and pharmacological interventions designed to slow the rate of aging and thus reduce the risk of age-related disease and functional decline. The major area of investigation involves in vivo rodent models and in vitro cellular models to identify protective mechanisms invoked by calorie restriction. Long-term calorie restriction has been shown in a wide variety of species to increase lifespan, decrease age-related disease, improve stress responses, and attenuate age-related functional impairments. As a major new research area, his lab is investigating the development of calorie restriction mimetics. The objective is to identify compounds that mimic effects of calorie restriction by targeting metabolic and stress response pathways affected, but without actually restricting caloric intake. Other major lab activities involve developing and conducting behavioral assays of aging in rodents with focus on motor and memory performance. The objective is to identify mechanisms of age-related decline in motor and memory performance. As a primary objective of this research, investigations are directed toward preclinical development of pharmacological, hormonal, genetic, and nutritional interventions that improve behavioral function. To identify age-related structural changes in the brain and alterations produced through various interventions, morphometric analysis using unbiased stereology is applied.
Selected Publications:

Roth GS, Mattison JA, Ottinger MA, Chachich M, Lane MA, Ingram DK. Aging in
rhesus monkeys: Relevance to human health interventions, Science, 305: 1423-1426, 2004.

Mamczarz J, Duffy K, Bowker J, Hagepanos A, Ingram D. Enhancement of amphetamine-induced locomotor response in rats on different regimens of diet restriction and 2-deoxyglucose treatment, Neuroscience, 131: 451-461, 2005.

Mattison J, Black A, Huck, J.,Moscrip T, Handy A,Tilmont T, Roth GS, Lane, MA, Ingram DK. Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiology of Aging, 26: 1117-1127, 2005.

Devan BD, Bowker JL, Bharati IS, Duffy KB, Nelson CM, Spangler EL, Ingram DK. The phosphodiesterase inhibitor sildenafil citrate attenuates the learning impairment in rats induced by nitric oxide synthase inhibition, Psychopharmacology, 183, 439-445, 2006.

Ingram DK, Zhu M, Mamczarz J, Zou S, Lane, MA, Roth GS, de Cabo R. Calorie restriction mimetics: An emerging research field. Aging Cell, 5: 97-108, 2006.

Lee GD, Longo D, Wang Y, Rifkind JM, Abdul-Raman L, Mamczarz JA, Duffy KB, BowkerJL, Spangler EL, Taub DD, Furukawa K, Mattson MP, Ingram DK. Cancer chemotherapy transiently improves cognitive function and synaptic plasticity in rats. Clinical Cancer Research. 12:198-205, 2006.

Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Vinayakuma VP, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy R, Fishbein KW, Spencer RG, Lakatta EG, LeCourteur D, Shaw RJ, Navas P, Puigerver P, Ingram DK, deCabo R, Sinclair DA. Resveratrol improves health and increases survival of mice on a high-calorie diet. Nature, 444: 337-342, 2006.

Devan, BD, Pistell, PJ, Daffin LW Jr, Nelson CM, Duffy KB, Bowker JL, Bharati IS, Sierra-Mercado D, Spangler EL, Ingram DK. Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor N?-nitro-L-arginine methyl ester. European Journal of Pharmacology, 563:134-140, 2007.

Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, DeCabo R, Mouton PR, Shukitt-Hale BA, Joseph JA, Ingram DK. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiology of Aging, 29: 1680-1689, 2007.

Ingram DK, Young J, Mattison JA. Calorie restriction in nonhuman primates: Assessing effects on brain and behavioral aging. Neuroscience, 145: 1359-1364, 2007.

Mattison JA, Roth GS, Lane MA, Ingram DK. Calorie restriction in aging nonhuman primates. In: Mobbs, C.V., Yen, K., Hof, P.R., (Eds): Mechanisms of Caloric Restriction in Aging. Interdisciplinary Topics in Gerontology Basel, Karger, 2007, vol 35, pp. 137-158.

O'Neil JN, Mouton PR, Tizabi Y, Ottinger MA, Lei DL, Ingram DK, Manaye KF. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. Journal of Chemical Neuroanatomy 34:102-107, 2007.

Pistell PJ, Daffin LW, Jr, Nelson CM, Duffy KB, Bowker JL, Spangler EL, Ingram DK, Devan BD. Combined administration of subthreshold doses of the nitric oxide inhibitor, nitro-L-arginine, and muscarinic receptor antagonist, scopolamine, impairs complex maze learning in rats. Behavioural Pharmacology.18: 801-805, 2007.

Stote KS, Baer DJ, Spears K, Paul DR, Harris GK, Rumpler WV, Strycular P, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Mattson MP. A controlled trial of reduced meal frequency without caloric restriction in healthy, normal weight middle-aged men and women. American Journal of Clinical Nutrition 85:981-988, 2007.

Allard JS, Heilbronn LK, Smith C, Hunt ND, Ingram DK, Ravussin E; Pennington CALERIE Team, de Cabo R. In vitro cellular adaptations of indicators of longevity in response to treatment with serum collected from humans on calorie restricted diets. PLoS ONE. 15:e3211, 2008.

Minor RK, Villarreal J, McGraw M, Percival SS, Ingram DK, de Cabo R. Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behavioural Brain Research, 189:202-211, 2008.

Komatsu T, Chiba T, Yamaza H, Yamashita M, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I. Manipulation of caloric content but not diet composition attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Experimental Gerontology, 43:339-346, 2008.

Pistell PJ, Zhu M, Ingram DK. Acquisition of conditioned taste aversion is impaired in the APP/PS1 mouse model of Alzheimer’s disease. Neuroscience, 152:594-600, 2008.

Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proceedings of the National Academy of Sciences, USA, 105:2325-2330, 2008.

Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span. Cell Metabolism. 8: 157-168, 2008.

Shukitt-Hale B, Lau FC, Carey AN, Galli RL, Spangler EL, Ingram DK, Joseph JA. Blueberry polyphenols attenuate kainic acid induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutritional Neuroscience 11: 172-182, 2008.

Stranahan AM, Lee K, Pistell P, Nelson CM, Readal N, Miller MG, Spangler EL, Ingram DK, Mattson MP. Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone. Neurobiology of Disease, 90: 479-83, 2008.

Umegaki H, Roth GS, Ingram DK. Aging of the striatum: Mechanisms and interventions, Journal of the American Aging Association, 30: 251-261, 2008.

Pistell PJ, Nelson CM, Miller MG, Ingram DK, Devan BD. Striatal lesions interfere with acquisition of a complex maze task in rats. Behavioural Brain Research, 197: 138-143, 2009.
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