Christopher Morrison, Ph.D.
Ph.D., University of Missouri - Columbia, MO, 2001, Animal Science, Reproductive Physiology and Neuroendocrinology
B.S., Louisiana State University, Baton Rouge, LA, 1997, Animal Science, Science and Technology Focus
Dr. Morrison has a general research interest in whole animal neuroendocrinology and physiology, especially as applied to the neuronal regulation of feeding behavior, body weight homeostasis, reproduction, growth, and metabolism. Of particular interest are the neuronal circuits and intracellular signaling molecules that respond to circulating nutritional signals and regulate food intake and metabolism. Dr. Morrison’s work has focused on the necessity of various intracellular signaling pathways in mediating leptin and insulin-dependant changes in food intake and neuropeptide gene expression, as well as the possibility that defects in these signaling pathways may contribute to obesity by impairing hypothalamic leptin and insulin action. More recent work has focused on the effects of altered dietary protein content on food intake and body weight, and in particular on the mechanisms through which variations in dietary protein content and circulating amino acids influence food intake and metabolism.
TG Anthony, CD Morrison, TW Gettys. Remodeling of lipid metabolism by dietary restriction of essential amino acids. Diabetes, In Press.
Laque A, Zhang Y, Gettys S, Nguyen TA, Bui K, Morrison CD, Münzberg H. Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. J Cell Biol. 2013 May 1;304(9):E999-E1011. doi: 10.1152/ajpendo.00643.2012. Epub 2013 Mar 12.PMID: 23482448 [PubMed - in process]
HR Berthoud, H Münzberg, BK Richards, CD Morrison. Neural and metabolic regulation of macronutrient intake and selection. Proc Nutr Soc. 3:390-400, 2012.
CD Morrison, SD Reed, TM Henagan. Homeostatic Regulation of Protein Intake: In Search of a Mechanism. Am J Physiol Regul Integr Comp Physiol. 302:R917-28, 2012.
MN Purpera, L Shen, M Taghavi, H Münzberg, RJ Martin, SM Hutson, CD Morrison.Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus. J Endocrinol. 212:85-94, 2012.
CD Morrison, PJ Pistell, DK Ingram, WD Johnson, Y Liu, SO Fernandez-Kim, CL White, MN Purpera, RM Uranga, AJ Bruce-Keller, JN Keller. High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. J Neurochem. 114:1581-9, 2010.
CL White, MN Purpera, K Ballard, CD Morrison. Decreased food intake following overfeeding involves leptin-dependent and leptin-independent mechanisms. Physiol Behav. 100:408-16, 2010.
T Babic, MN Purpera, BW Banfield, HR Berthoud, CD Morrison. Innervation of skeletal muscle by leptin receptor-containing neurons. Brain Res. 1345:146-55, 2010.
AJ Bruce-Keller, CL White, A Gupta, AG Knight, PJ Pistell, DK Ingram, CD Morrison, JN Keller. NOX activity in brain aging: exacerbation by high fat diet. Free Radic Biol Med. 49:22-30, 2010.
CL White, PJ Pistell, MN Purpera, S Gupta, OS Fernandez-Kim, TL Hise, JN Keller, DK Ingram, CD Morrison, and AJ Bruce-Keller. Effects of High Fat Diet on Morris Maze Performance, Oxidative Stress, and Inflammation in Rats: Contributions of Maternal Diet. Neurobiology of Disease, 125(3):603-11, 2009.
CL White, MN Purpera, CD Morrison. Maternal obesity is necessary for the programming effect of a high-fat diet on offspring. Am J Physiol Regul Integr Comp Physiol. R1464-72, 2009.
CL White, A Whittington, MJ Barnes, Z Wang, X Xi, RJ Martin, GA Bray, CD Morrison. HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and independent mechanisms. American Journal of Physiology - Endocrinology & Metabolism 296:E291-9, 2009.
CD Morrison. Leptin resistance and the response to positive energy balance. Physiology & Behavior 94: 660–663, 2008.
HR Berthoud and C Morrison. The brain, appetite, and obesity. Annual Reviews of Psychology 59:55-92, 2008.
CD Morrison, X Xi, CL White, J Ye, RJ Martin. Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism. Am J Physiol Endocrinol Metab. 293:E165-71, 2007.
For a complete list of publications, visit ResearcherID