RESEARCH & FACULTY

Elizabeth Floyd, Ph.D. Assistant Professor Department/Laboratory: Ubiquitin Lab
Phone: (225) 763-2724	Fax: (225) 763-0273
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EDUCATION

Ph.D., Louisiana State University, Baton Rouge, LA, 1997, Biochemistry
B.S., Univesity of Alabama at Birmingham, Birmingham, AL, 1977, Nursing

RESEARCH INTERESTS

Dr. Floyd has a general interest in protein turnover mediated by the ubiquitin-proteasome system. In particular, she is interested in understanding how the ubiquitin-proteasome pathway affects the activity of nuclear proteins such as transcription factors. Her research is currently focused on how ubiquitin and ubiquitin-like modifications regulate the activity of the peroxisome proliferator-activated receptor gamma (PPARg), a nuclear hormone receptor required for the formation of adipocytes.

SELECTED PUBLICATIONS

Floyd ZE, Stephens JM. Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation. Obes Res. 2004 Jun;12(6):921-8.

Floyd ZE, Stephens JM. STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes. 2003 Feb;52(2):308-14

Floyd ZE, Stephens JM. Chapter 3: STAT5A promotes adipogenesis in nonprecursor cells. In Proceedings of Progress in Obesity 9, G Medeiros-Neto, A Halpern and C Bouchard, eds. John Libbey, Eurotext, 2003

Floyd, Z.E. and Stephens, J.M. (2002) IFN gamma-mediated activation and ubiquitin-proteasome dependent degradation of PPAR gamma in adipocytes. J. Biol. Chem. 277, 4062-4068.

Waite, K.J., Floyd, Z.E., Arbour-Riley, P., Stephens, J.M. (2001) Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes. J. Biol. Chem. 276, 7062-7068.

Floyd, Z.E., Trausch-Azar, J.S., Reinstein, E., Ciechanover, A., Schwartz, A.L. (2001) The Nuclear Ubiquitin-Proteasome System Degrades MyoD. J. Biol. Chem. 276, 22468-22475. ^ top