Randall Mynatt, Ph.D.
Ph.D., University of Tennessee, Knoxville, TN, 1991, Nutrition Sciences
Dr. Mynatt is the Director of the Transgenic and Gene Targeting Facility. His areas of interest are the regulation of adipogenesis and adipocyte function by the agouti/melanocortin system. Agouti/melanocortins are part of a communication circuit between the brain and adipose tissue which conveys centrally-mediated signals and modulates adipocytes responsiveness to these signals. The focus of his research is to understand both the mechanisms of agouti/melanocortin action on preadipocytes and adipocytes and the basis for how these effects on adipocyte function contribute to obesity.
Mynatt RL, and Stephens JM. Agouti regulates adipocyte transcription factors. Am. J. Phys. Cell Physiol. 2001; 280:101-105
Harris, RBS, Zhou, J, Shi, M, Redmann, S, Mynatt, RL and Ryan, DH. Over-Expression of Agouti Protein and Stress Responsiveness in Mice. Physiol Behav. 2001 Jul;73(4):599-608.
Harris, RBS, Mitchell, TD and Mynatt, RL Leptin Responsiveness in Mice That Ectopically Express Agouti
Protein Physiol Behav. 2002; 75:159-167
Zvonic, S, Cornelius, P, Stewart, WC, Mynatt, RL, and Stephens, J M. The regulation and activation of CNTF signaling proteins in adipocytes. J Biol Chem 2002; 278:2228-2235
Janderová, L, McNeil, M, Murrell, AN, Mynatt, RL and Smith, SR. Human mesenchymal stem cells as an in vitro model for human adipogenesis Obesity Research. 2003; 11:65-74
Zvonic S, Story, DJ, Stephens, JM and Mynatt, RL. Growth Hormone, but not insulin, activates STAT5 proteins in adipocytes in vitro and in vivo Biochem Biophys Res Commun. 2003; 302:359-362
Mynatt, RL and Stephens, JM. Regulation of PPARgamma and obesity by agouti/melanocortin signaling in adipocytes Ann N Y Acad Sci. 2003; 994:141-146
Albarado, DC, Mcclaine, J, Stephens, JM, Mynatt, RL, Ye, J, Bannon, AW, Richards, WG, and Butler, AA. Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice Endocrinology. 2004; 145:243-252
Smith, SR, Gawronska-Kozak, B, Janderova, L, Nguyen, T, Murrell, A, Stephens, JM, and Mynatt, RL. Agouti expression in human adipose tissue: functional consequences and increased expression in type 2 diabetes Diabetes. 2003; 52:2914-2922
Kuklin, AI, Mynatt, RL , Klebig, ML, Kiefer, LL, Wildison, WO, Woychik, RP and Michaund, EJ. Liver-specific expression of the agouti gene in transgenic mice promotes liver carcinogenesis in the absence of obesity and diabetes Mol Cancer. 2004; 02:17.
Zvonic, S, Hogan, JC, Arbour-Reily, P, Mynatt, RL, and Stephens, JM. The action of Cardiotrophin-1 (CT-1) on adipocytes. J Biol Chem. 2004 Nov 12;279(46):47572-9.
Zvoinc, S, Arbour-Reily, P, Mynatt, RL, and Stephens, JM. Cross talk among gp130 cytokines in adipocytes. J Biol Chem, 280:33856-33863, 2005.
Rim, JS, Mynatt, RL and Gawronska-Kozak, B. Mesenchymal stem cells from the outer ear: a novel adult stem cell model system for the study of adipogenesis. FASEB Journal, 19:1205-1207, 2005.
Zhang, Y, Kilroy,GE, Henagan,T, Prpic-Uhing, V, Richards, WG, Bannon, AW, Mynatt, RL and Thomas W. Gettys. Targeted Deletion of Melanocortin Receptor Subtypes 3 and 4, but not CART, Alters Nutrient Partitioning and Comprises Behavioral and Metabolic Responses to Leptin. FASEB Journal, 19:1482-1491, 2005.
Sparks, LM, Xie, H, Koza, RA, Mynatt, RL, Bray, GA, and Smith, SR. A High Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle. Diabetes 54:1926-1933, 2005.
Zvonic S, Ptitsyn AA, Conrad SA, Scott LK, Floyd ZE, Kilroy G, Wu X, Goh BC, Mynatt RL, and Gimble JM. Characterization of peripheral circadian clocks in adipose tissues. Diabetes 55:962-970, 2006.
Ptitsyn AA, Zvonic S, Conrad SA, Scott LK, Mynatt RL and Gimble JM. Circadian clocks are resounding in peripheral tissues. PLOS Computational Biology 10:e16, 2006.
Hausman GJ, Poulos SP, Richardson LR, Barb CR, Andacht T, Kirk HC, and Mynatt RL. Secreted proteins and genes in fetal and neonatal pig adipose tissue and stromal-vascular cells. Journal of Animal Science 84:1666-1681, 2006.
Sparks LM, Xie H, Koza RA, Mynatt RL, Bray GA, and Smith, SR. High-fat/low-carbohydrate diets regulate glucose metabolism via a long-term transcriptional loop. Metabolism 55:1457-1463, 2006.
Power RA, Hulver MW, Zhang JY, Dubois J, Marchand RM, Ilkayeva O, Muoio DM and Mynatt RL. Carnitine Revisited: Potential use ad Adjunctive Treatment in Diabetes. Diabetologia, 2007. (In Press)