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Heike Muenzberg-Gruening,
Assistant Professor
Department/Laboratory:
Leptin Signaling in the Brain
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Phone:
(225) 763-2769
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Fax:
(225) 763-0260 |
Send
E-mail
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Education:
Ph.D., University Hospital Hamburg and Universtiy Hospital Heidelberg, Germany (Biology)
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Research
Interests:
Interaction of melanocortin and leptin signaling
Arcuate nucleus specific leptin resistance and inhibitory leptin signaling molecules.
Central leptin signaling pathways.
The leptin signaling system in the dorsomedial hypothalamus and sympathetic connection to peripheral tissues.
Interaction of the leptin signaling system in the arcuate nucleus and dorsomedial hypothalamus with emphasis on leptin receptor expressing galanin neurons.
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Selected
Publications:
Leshan RL, Björnholm M, Münzberg H, Myers MG Jr: Leptin receptor signaling and action in the central nervous system. Obesity. 2006 Suppl 5:208S-212S.
Münzberg H, Jobst E, Bates SH, Jones JC, Villanueva E, Leshan RL, Björnholm M, Elmquist J, Sleeman M, Cowley M, Myers MG Jr: Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling. J. Neurosc 27(1):69-74, 2007
Björnholm M, Münzberg H, Leshan RL, Bates SH, Louis GW, Villanueva EC, Jones JC, Ishida-Takahashi R, Myers MG: Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function. J Clin Inv accepted Feb 2007
Faouzi M, Leshan R, Björnholm M, Hennessey T, Jones JC and Münzberg H: Differential Accessibility of Circulating Leptin to Individual Hypothalamic Sites. Endocrinology, 148(11):5414-23, 2007
Gong Y, Ishida-Takahashi R, Villanueve EC, Fingar DC, Münzberg H, Myers MG Jr.: The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. J Biol Chem, 282(42):31019-27, 2007
Plum L, Rother E, Münzberg H (3/15), Brüning JC: Enhanced leptin-stimulated pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metab., 6(6):431-45, 2007
Lee JY, Muenzberg H, Gavrilova O, Reed JA, Berryman D, Villanueva EC, Louis GW, Leinninger GM, Bertuzzi S, Seeley RJ, Robinson GW, Myers MG, Hennighausen L: Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity. PLoS ONE, 3(2):e1639, 2008
Mori H, Inoki K, Münzberg H, Opland D, Faouzi M, Villanueva EC, Ikenoue T, Kwiatkowski D, MacDougald OA, Myers MG Jr, Guan KL. Critical role for hypothalamic mTOR activity in energy balance. Cell Metab 9(4):362-74, 2008
Münzberg H: Differential Leptin Access into the Brain – A Hierarchical Organization of Hypothalamic Leptin Target Sites? Physiol Behav. 94:664-9, 2008
Leshan RL, Louis GW, Jo YH, Rhodes CJ, Münzberg H, Myers MG Jr. Direct innervations of GNRH neurons by metabolic-and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus. J Neurosci 29(10):3138-47, 2009
Myers MG Jr, Münzberg H, Leinninger GM, Leshan RL. The geometry of leptin action in the brain: more complicated than simple ARC. Cell Metab. 9(2):117-23, 2009.
Villanueva EC, Münzberg H, Cota D, Leshan RL, Kopp K, Ishida-Takahashi R, Jones JC, Fingar DC, Seeley RJ, Myers MG Jr. Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology 150(10):4541-5, 2009.
Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S Jr, Diano S, Horvath TL, Seeley RJ, Becker JB, Münzberg H, Myers MG Jr. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab 10(2):89-98, 2009.
Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT. Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. J Neurosci. 29(37):11582-93, 2009.
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