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William Cefalu, M.D.
Douglas L. Manship Professorship in Diabetes
Professor, Chief Nutrition/Chronic Disease
Department/Laboratory:
Diabetes and Nutrition
Inpatient Unit
John S. McIlhenny Botanical Research
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Phone:
(225) 763-2658
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Fax:
(225) 763-0274 |
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E-mail
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Education:
M.D., Louisiana State University Medical. School, New Orleans, LA, 1979, Medicine
B.S., Southeastern Louisiana University, Hammond, LA, 1975, Biology
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Research
Interests:
Dr. Cefalu's research is active at both the clinical and basic levels. On a clinical level, he is interested in clinical interventions to improve the metabolic state of individuals with insulin resistance and type 2 diabetes. Such interventions have included novel delivery systems for insulin and nutritional modulations. The nutritional approaches include caloric restriction, chromium supplementation, and novel botanical extracts. The clinical research techniques employed include the use of the hyperglycemic euglycemic clamp. As part of the clinical research, biopsies are taken for analysis in the laboratory. In the Lab, his interests are primarily in the area of insulin resistance and the study of the potential mechanisms. His is currently in the first year of a 4 year research project from the NIH which will examine the clinical effect of Chromium on insulin action in Type 2 diabetes, and his lab will explore potential mechanisms of action. He also is in the last year of an award from the American Diabetes Association assessing the clinical effect of chromium supplementation on glycemia in type 2 diabetes. Several clinical projects are ongoing including the effect of an extract of tarralin on glucose control in type 2 diabetes, and the use of inhaled insulin.
Affiliations:
Council for the Advancement of Diabetes Research and Education
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Selected
Publications:
Cefalu WT. Evolving strategies for insulin delivery and therapy. Drugs. 2004;64(11):1149-61
Cefalu WT. Concept, Strategies, and Feasibility of Non-Invasive Insulin Delivery. Diabetes Care 27: 239-246, 2004
Cefalu, WT, Edwards, IJ, Wagner, JD, Vogl-Willis, CA, Litwak, KN. Arterial heparin sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys. Cardiovascular Diabetology 29;3(1): 6 2004
Cefalu WT, Wang, ZQ, Schneider DJ, Absher, PM, Baldor LC, Taatjes D, Sobel BE. Effects of insulin sensitizers on plaque vulnerability associated with elevated lipid content in atheroma in ApoE-knockout mice. Acta Diabetol 2004 Mar; 41(1):25-31.
CADRE's Handbook of Diabetes Management. Cefalu WT, Leroith D, Gerich J, eds. CMD Publishing, New York, NY, 2004
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