Volunteer, donation, and assistance resources regarding the August 2016 floods in our area are available here:
South Louisiana Flood Info & Resources


Study Type


Study Purpose

Researchers at Pennington Biomedical are looking for individuals to participate in a type 2 diabetes research study comparing the effects of four commonly used, FDA approved diabetes medications to maintain normal blood glucose (blood sugar) levels.

About the Study

Type 2 diabetes is a growing epidemic that is on track to becoming the century's foremost public health concern. Type 2 diabetes poses enormous human and economic challenges worldwide as most people with diabetes will eventually need two medications to control blood glucose (blood sugar) levels.

A major challenge in treating type 2 diabetes is determining which drug option is the best choice for people already being treated with metformin, the most commonly used diabetes drug.

Our GRADE study will test which combination of two medications is best for glycemic control, which has the fewest side effects, and which combination is the most beneficial for overall health.

Study Design

Number of visits:

  • 3-4 screening visits
  • Quarterly and annual outpatient visits until end of study

Study procedures:

  • Height, weight, vitals
  • Blood draws
  • Urine samples
  • Questionnaires
  • Memory testing
  • Foot exams
  • Oral Glucose Tolerance Test (OGTT)
  • Diabetes education

After completion of all screening visits, eligible participants will be randomly assigned to one of four treatment groups. These treatment groups consist of four commonly used, FDA approved diabetes medications (glimepiride, sitagliptin, liraglutide, and basal insulin glargine), plus metformin. Volunteers will be followed for up to 7 years to evaluate their relative effectiveness in achieving good glycemic control and on overall health. Volunteers will receive diabetes medications, diabetes education and all study related procedures at no cost.

Study Qualifications

  • Age: ≥ 30 years old (≥ 20 years for American Indians) at age of diabetes diagnosis
  • Diagnosed with Type 2 diabetes within the last 10 years
  • Currently taking only Metformin for Type 2 diabetes
  • HbA1c ≥ 6.8%

Study Duration



Participants will be compensated up to $125/year of participation.

Study Contact

If you are interested in volunteering for the GRADE study, click here to screen online, call 225-763-3000 or email clinicaltrials@pbrc.edu.

If you think you may be eligible, please click the button below to screen online.


Please do not fill out this questionnaire for anyone other than yourself unless you are their legal guardian.
If you know someone who may be interested please direct them to the site or have them call us directly at 225-763-3000.


English Calculation
Enter Your Weight: 
Enter Your Height: 
 ft.  in.
Your BMI: