Mark Sarzynski, Ph.D.
Assistant Professor - Research
B.S. - Physiology, Michigan State University
Ph.D. - Exercise Physiology, Michigan State University
Postdoctoral Fellowship - Human Genomics Laboratory, Pennington Biomedical Research Center
My current research employs an integrated genomic, transcriptomic, and proteomic approach to identify and characterize the biological factors associated with the response of lipids and lipoproteins to behavioral interventions, particularly high density lipoprotein (HDL) particles and related traits. The goal is to better predict which individuals are most likely to benefit from lifestyle therapies in the management of dyslipidemias and the overall lipid profile.
Loos RJF, Rankinen T, Hagberg JM, Perusse L, Roth SM, Sarzynski MA, Wolfarth B, Bouchard C. Advances in Exercise, Fitness, and Performance Genomics in 2014. Medicine & Science in Sports & Exercise (in press) PMID: 25706296
Rankinen T, Sarzynski MA, Ghosh S, Bouchard C. Are there genetic paths common to adiposity, cardiovascular disease outcomes and cardiovascular risk factors? Circulation Research 2015; 116: 909-922. PMID: 25722444
Locke AE et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015; 518: 197-206. PMID: 25673413
Shungin D et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015; 518: 187-196. PMCID: PMC4338562
Pers et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications 2015; 6:5890. PMID: 25597830
Bouchard C, Antunes-Correa LM, Ashley EA, Franklin N, Hwang PM, Mattson M, Negrao CE, Phillips SA, Sarzynski MA, Wang PY, Wheeler M. Personalized Preventive Medicine: Genetics and the Response to Regular Exercise in Preventive Interventions. Progress in Cardiovascular Disease 2015; 57: 337-346. PMCID: PMC4285566
Staiano AE, Harrington DM, Johannsen NM, Newton RL, Sarzynski MA, Swift DL, Katzmarzyk PK. Uncovering physiological mechanisms for health disparities in type 2 diabetes. Ethnicity & Disease 2015; 25(1): 31-37.
Wood AR et al. Defining the role of common variation in the genomic and biological
architecture of adult human height. Nature Genetics 2014; 46(11): 1173-1186. PMCID: PMC4250049
Raja GK, Sarzynski MA, Katzmarzyk PT, Johnson WD, Tchoukalova Y, Smith SR, Bouchard C. Commonality versus specificity among primary adiposity traits. International Journal of Obesity 2014; 38: 719-723.
Wolfarth B, Rankinen T, Hagberg JM, Loos RJF, Perusse L, Roth SM, Sarzynski MA, Bouchard C. Advances in Exercise, Fitness, and Performance Genomics in 2013. Medicine & Science in Sports & Exercise 2014; 46(5): 851-859.
Sarzynski MA and Bouchard C. The challenging chase for nutrigenetic predictors of metabolic responses to dietary interventions. Diabetes Care 2013; 36(11): 3379-3381.
Ghosh S, Vivar JC, Sarzynski MA, Sung YJ, Timmons JA, Bouchard C, Rankinen T. Integrative Pathway analysis of a Genome-Wide Association Study of VO2max Response to Exercise Training. Journal of Applied Physiology 2013; 115(9): 1343-1359.
Sarzynski MA, Rankinen T, Earnest CP, Leon AS, Rao DC, Skinner JS, Bouchard C. Measured maximal heart rates compared to commonly used age-based prediction equations in the HERITAGE Family Study. American Journal of Human Biology 2013; 25(5): 695-701.
Perusse L, Rankinen T, Hagberg JM, Loos RJF, Roth SM, Sarzynski MA, Wolfarth B, Bouchard C. Advances in Exercise, Fitness, and Performance Genomics in 2012. Medicine & Science in Sports & Exercise 2013; 45(5): 824-831.
Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjöström L, Bouchard C, Carlsson LMS. Changes in uric acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish Obese Subjects study. PLoS ONE 2012; 7(12): e51658.
Rice TK, Sarzynski MA, Sung YJ, Argyropoulos G, Stütz AM, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T. Fine mapping of a QTL on chromosome 13 for indicators of submaximal exercise capacity in the HERITAGE Family Study. European Journal of Applied Physiology 2012; 112(8): 2969-2978.
Bouchard C, Blair SN, ChurchTS, Earnest CP, Hagberg JM, Hakkinen K, Jenkins NT, Karavirta L, Kraus WE, Leon AS, Rao DC, Sarzynski MA, Skinner JS, Slentz CA, Rankinen. Adverse Response to Regular Exercise: Is It a Rare or Common Occurrence? Plos One 2012; 7(5): e37887.
Roth SM, Rankinen T, Hagberg JM, Loos RJF, Perusse L, Sarzynski MA, Wolfarth B, Bouchard C. Advances in Exercise, Fitness, and Performance Genomics in 2011. Medicine & Science in Sports & Exercise 2012; 44(5): 809-817.
Rankinen T, Sun YJ, Sarzynski MA, Rice TK, Rao DC, Bouchard C. Heritability of submaximal exercise heart rate response to regular exercise is accounted for by nine SNPs. Journal of Applied Physiology 2012; 112: 892-897.
Sarzynski MA, Rankinen T, Sternfeld B, Fornage M, Sidney S, Bouchard C. SNP-by-fitness and SNP-by-BMI interactions from 7 candidate genes and incident hypertension after 20 years of follow-up: The CARDIA Study. Journal of Human Hypertension 2011; 25: 509-518.
Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjöström L, Carlsson LMS, Bouchard C. Association of GWAS-based candidate genes with HDL-C levels before and after bariatric surgery in the Swedish Obese Subjects intervention study. Journal of Clinical Endocrinology and Metabolism 2011; 96(6): E953-7.
Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjöström L, Bouchard C, Carlsson LMS. Associations between markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. International Journal of Obesity. 2011; 35(5): 676-683.
Bouchard C, Sarzynski MA, Rice T, Kraus WE, Church TS, Sung YJ, Rao DC, Rankinen T. Genomic predictors of maximal oxygen uptake response to standardized exercise training programs. Journal of Applied Physiology. 2011; 110: 1160-1170.
Sarzynski MA, Rankinen T, Sternfeld B, Grove ML, Fornage M, Jacobs DR Jr, Sidney S, Bouchard C. Association of SNPs from 17 candidate genes with baseline symptom-limited exercise test duration and change in duration over 20 years: The CARDIA Fitness Study. Circulation: Cardiovascular Genetics. 2010; 3: 531-538.
Eisenmann JC, Sarzynski MA, Tucker J, Heelan KA. Maternal pre-pregnancy overweight and offspring fatness and blood pressure: role of physical activity. Pediatric Exercise Science. 2010; 22(3): 369-378.
Sarzynski MA, Eisenmann JC, Heelan KA, Glenn K. ACE I/D genotype, habitual physical activity, and blood pressure in children. Pediatric Exercise Science. 2010; 22(2): 301-313.
Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NBJ, Nielsen S, Åkerström T, MacDougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, van Loon LJC, Pedersen BK, Sundberg CJ, Wahlestedt C, Britton SL, Bouchard C. Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. Journal of Applied Physiology. 2010; 108: 1487-1496.
Eisenmann JC, Sarzynski MA, Heelan KA, Glenn K, Rothschild M. ACE I/D genotype, adiposity, and blood pressure in children. Cardiovascular Diabetology. 2009; 8(1):14.