Study Type

General Health & Wellbeing

Study Purpose

The purpose of this study is to compare the metabolic effects of metformin versus a placebo in patients with obstructive sleep apnea.

About the Study

Two screening visits to PBRC will determine eligibility. The first screen will last approximately 2 hours and the second screen will require an overnight stay to complete a sleep study. 

Eligible participants will have 4 study visits, approximately 1 month apart. Participants will be provided equipment for positive airway pressure therapy for the treatment of sleep apnea. Once participation in the study is completed, participants will be allowed to keep this equipment. The participant will also be asked to take a daily study drug or a placebo, which will be provided.

Study Design

Number of Visits:

  • 2 screening visits (1 overnight)
  • 4 study visits


  • Medical history and physical examination
  • Vital signs
  • Height, weight and body measurements
  • Blood draws
  • Urine tests
  • Food activity logs
  • Body Fat Concentration Measurement
  • Standard OSA therapy using Positive Airway Pressure
  • Fat and muscle biopsies
  • DXA – measures the amount of bone, muscle, and fat in your body
  • OGTT – oral glucose tolerance test
  • Questionnaires

Study Qualifications

To qualify for this research study, participants should:

  • Be between the ages of 35 and 65
  • Have a Body Mass Index (BMI) between 30 - 50 calculate your BMI
  • Not have evidence or diagnosis of diabetes
  • Potentially have moderate to severe sleep apnea. Symptoms of sleep apnea can include: loud snoring, gasping for air during sleep, unrefreshing sleep, awakening with dry mouth, morning headaches, and daytime fatigue or sleepiness.

Study Duration

Participation in the study will last approximately 4 months, with 2 screening visits and 4 study visits.


Compensation of up to $300 and equipment to treat sleep apnea is offered for the completion of this study.

Study Contact

If you are interested in volunteering for this research study, click here to screen online. Interested volunteers may also call 225-763-3000 or email

If you think you may be eligible, please click the button below to screen online.


Please do not fill out this questionnaire for anyone other than yourself unless you are their legal guardian.
If you know someone who may be interested please direct them to the site or have them call us directly at 225-763-3000.


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