EAT 2 Study

Study Type

General Health & Wellbeing

Study Purpose

Recent studies have shown that new adipocytes (fat cells) are constantly formed in the human body and that the ability to expand the fat tissue during changes in body weight is important for health.

The EAT 2 research study will look at the changes that occur in the fat tissue as a result of

weight gain (and weight loss) and the effects on your health.

About the Study

Once enrolled, participants will be randomly assigned to either a control (weight stable) or overfeeding group. Both groups will partake in an 8-week dietary intervention program. Participants in the overfeeding group will be provided weight loss treatment for 8-weeks after the intervention.

This study requires 2 overnight stays in the Pennington Biomedical Inpatient Unit.

Study Design

Number of Visits:

  • 1 screening visit
  • 11 study visits


  • Blood draws
  • Drinking doubly labeled/heavy water
  • Dietary intervention
  • Fat biopsies
  • DXA scans
  • MRI and 1MRS scans
  • Insulin Sensitivity Test
  • Overnight stays at PBRC on 2 occasions

Study Qualifications

To qualify for this research study, participants should:

  • Be a man or pre-menopausal woman
  • Be 18-42 years of age
  • Have a BMI between 25 – 30 calculate your BMI
  • Be willing to drink heavy water for 8 weeks

*You may not qualify for this study based on other eligibility criteria. The study coordinator will go over this information in detail.

Study Duration

Participation in this research study will last approximately 9 months.


Compensation of up to $1,255 is offered for the completion of this study.

Study Contact

If you are interested in volunteering for this research study, click here to screen online, call 225-763-3000 or email

If you think you may be eligible, please click the button below to screen online.


Please do not fill out this questionnaire for anyone other than yourself unless you are their legal guardian.
If you know someone who may be interested please direct them to the site or have them call us directly at 225-763-3000.


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