EXPEND Study

Study Type

Weight Loss/Obesity

Study Purpose

When diet and exercise are not enough to achieve weight management goals, oftentimes a medication is recommended to achieve necessary weight loss.

The EXPEND research study will assess the effectiveness of the study drug for weight loss. The study will also examine the effect of the study drug on metabolism while sleeping.

About the Study

Eligible participants will visit the Pennington Biomedical clinic at the beginning of the study and stay on site in the Inpatient unit for 6 days and 5 nights. Participants will be randomly assigned to receive the study medication or placebo.

Following the onsite stay, participants will visit Pennington Biomedical once a week for 17 weeks. The 18th week of treatment subjects will check back into the Inpatient unit to stay for 5 days and 4 nights.

Study Design

Number of Visits:

  • 1 screening visit
  • 21 study visits (including multiple overnight stays in the Pennington Biomedical Inpatient Unit)

Procedures:

  • Medical history
  • Height and weight
  • Vital signs (pulse and blood pressure, etc.)
  • Lifestyle interview
  • Physical exam
  • Electrocardiogram (ECG) to determine heart health
  • DXA Scan to measure bone density, muscle, and body fat
  • Pregnancy tests
  • Metabolic Chamber
  • Oral glucose tolerance test
  • Blood tests
  • Urine tests
  • Tissue sampling
  • Appetite and food craving assessments
  • Questionnaires

Study Qualifications

To qualify for this research study, participants should:

  • Be between the ages of 18 – 60 years old
  • Have a BMI between 30-45 calculate your BMI
  • Not be pregnant

Study Duration

Participation in this research study will last approximately 28 weeks.

Compensation

Compensation of up to $1,850 is offered for completion of this study.

Study Contact

If you are interested in volunteering for this research study, click here to screen online, call 225-763-3000 or e-mail clinicaltrials@pbrc.edu.

If you think you may be eligible, please click the button below to screen online.

GET STARTED

Please do not fill out this questionnaire for anyone other than yourself unless you are their legal guardian.
If you know someone who may be interested please direct them to the site or have them call us directly at 225-763-3000.

CALCULATE YOUR BMI

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