MoTrPAC Study

Study Type

Physical Activity

Study Purpose

For years, we have known that being physically active is good for our health, but there is not a clear understanding of what actually happens deep within the body or how our molecules change to improve health when we exercise.

Molecular Transducers of Physical Activity Consortium (MoTrPAC) is a nationwide study, and the largest effort to date, aimed at understanding how physical activity improves health and prevents disease. The main goal of the MoTrPAC research study is to gain a better understanding of how the body changes with physical activity. This will help researchers and doctors to prescribe tailored exercise procedures in the future.

About the Study

Participants will visit the Pennington Biomedical outpatient clinic for an orientation to learn more about the study. If interesting in participating in MoTrPAC, participants will attend a screening visit to determine if you are eligible for the study. Once enrolled, participants will be randomly assigned to a 12-week intervention of either a resistance exercise training, endurance exercise training, or control group.

If assigned to one of the two exercise groups, participants will visit the Pennington Biomedical fitness center three days a week for 12 weeks to engage in exercise training with onsite trainer. Various tissue sampling will be performed at different points during the study to assess how your body is changing as you exercise.

Study Design

Number of Visits:

  • 1 orientation visit
  • 1 screening visit
  • up to 8 study visits
  • up to 2-3 practice exercise sessions
  • Exercise training 3 days a week for 12 weeks


  • Medical history
  • Height and weight
  • Vital signs (pulse and blood pressure)
  • Physical exam
  • Strength measurements
  • Fitness testing
  • Physical activity and dietary pattern assessments
  • Electrocardiogram (ECG) to determine heart health
  • DXA Scan to measure bone density, muscle, and body fat
  • Pregnancy tests
  • Tissue samples
  • Blood tests
  • Questionnaires

Study Qualifications

To qualify for this research study, participants should:

  •  Be 18 years of age or older
  • Have a BMI between 19 – 35 calculate your BMI
  • Have no history of diabetes or heart disease
  • Exercise 1 time a week or less
  • Be willing to have study-related health exams and exercise with a personal trainer for 12 weeks

* You may not qualify for this study based on other eligibility criteria not listed. The study coordinator will go over this information in detail.

Study Duration

Participation in this research study will last approximately 6 months.


Compensation of up to $1500 is offered for the completion of this study.

Study Contact

If you are interested in volunteering for this research study, click here to screen online, call 225-763-3000 or

If you think you may be eligible, please click the button below to screen online.


Please do not fill out this questionnaire for anyone other than yourself unless you are their legal guardian.
If you know someone who may be interested please direct them to the site or have them call us directly at 225-763-3000.


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