Donald Ingram, Ph.D.
Nutritional Neuroscience and Aging
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Louisiana State University, Baton Rouge, LA B.A. 1966-1970 Psychology
University of Georgia, Athens, GA M.S. 1974-1977 Psychology
University of Georgia, Athens, GA Ph.D. 1977-1978 Psych & Gerontology
The Jackson Laboratory, Bar Harbor, ME Post-doc 1978-1980 Behavior Genetics
National Institute on Aging, NIH, Baltimore, MD Staff Fellow 1980-1984 Neurobiology of Aging
Position prior to joining PBRC:
Chief, Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD
Dr. Ingram’s research has focused on nutritional and pharmacological interventions designed to slow the rate of aging and thus reduce the risk of age-related disease and functional decline. The major area of investigation involves in vivo rodent models and in vitro cellular models to identify protective mechanisms invoked by calorie restriction. Long-term calorie restriction has been shown in a wide variety of species to increase lifespan, decrease age-related disease, improve stress responses, and attenuate age-related functional impairments. As a major new research area, his lab is investigating the development of calorie restriction mimetics. The objective is to identify compounds that mimic effects of calorie restriction by targeting metabolic and stress response pathways affected, but without actually restricting caloric intake. Other major lab activities involve developing and conducting behavioral assays of aging in rodents with focus on motor and memory performance. The objective is to identify mechanisms of age-related decline in motor and memory performance. As a primary objective of this research, investigations are directed toward preclinical development of pharmacological, hormonal, genetic, and nutritional interventions that improve behavioral function. To identify age-related structural changes in the brain and alterations produced through various interventions, morphometric analysis using unbiased stereology is applied.
Urbanski HF, Mattison JA, Roth GS, Ingram DK. Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies. Exp Gerontol. 2013, in press.
Chiu JC, Kaub K, Zou S, Liedo P, Altamirano-Robles L, Ingram D, Carey JR. Deleterious effect of suboptimal diet on rest-activity cycle in Anastrepha ludens manifests itself with age. Sci Reports. 3 : 1773 | DOI: 10.1038/srep01773.
Pistell P, Spangler EL, Kelly-Bell B, Miller MG, de Cabo R, Ingram DK. Age-associated learning and memory deficits in two mouse versions of the Stone T-maze. Neurobiol Aging. 33:2431-9, 2012.
Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R.Impact of caloric restriction on health and survival in rhesus monkeys from theNIA study. Nature. Sep 13;489(7415):318-21, 2012.
Gupta S, Knight AG, Losso BY, Ingram DK, Keller JN, Bruce-Keller AJ. Brain injury caused by HIV protease inhibitors: Role of lipodystrophy and insulin resistance. Antiviral Res. 95(1):19-29, 2012.
Liedo P, Carey JR, Ingram DK, Zou S. The interplay among dietary fat, sugar, protein and açai (Euterpe oleracea Mart.) pulp in modulating lifespan and reproduction in a Tephritid fruit fly. Exp Gerontol. 47(7):536-9, 2012.
De Guzman JM, Ku G, Fahey R, Youm YH, Kass I, Ingram DK, Dixit VD, Kheterpal I. Chronic caloric restriction partially protects against age-related alteration in serum metabolome. Age (Dordr). 2012 Jun 4. [Epub ahead of print]
Mouton PR, Kelley-Bell B, Tweedie D, Spangler EL, Perez E, Carlson OD, Short RG, de Cabo R, Chang J, Ingram DK, Li Y, Greig NH. The effects of age and lipopolysaccharide (LPS)-mediated peripheral inflammation on numbers of central catecholaminergic neurons. Neurobiol Aging. 33(2):423.e27-36, 2012.
Garcia-San Frutos M, Pistell PJ, Ingram DK, Berthoud H-R. Feed efficiency, food choice, and food reward behaviors in young and old Fischer rats. Neurobiol Aging. 33(1):206.e41-53, 2011.
Smith DL Jr, Mattison JA, Desmond RA, Gardner JP, Kimura M, Roth GS, Ingram DK, Allison DB, Aviv A. Telomere dynamics in rhesus monkeys: No apparent effect of caloric restriction. J Gerontol A Biol Sci Med Sci. 66(11):1163-8, 2011.
Qiu G, Wan R, Hu J, Mattson MP, Spangler E, Liu S, Yau SY, Lee TM, Gleichmann M, Ingram DK, So KF, Zou S. Adiponectin protects rat hippocampal neurons against excitotoxicity. Age (Dordr). 33(2):155-65, 2011.
Zou S, Liedo P, Altamirano-Robles L, Cruz-Enriquez J, Morice A, Ingram DK, Kaub K, Papadopoulos N, Carey JR. Recording lifetime behavior and movement in an invertebrate model. PLoS One. 6(4):e18151, 2011.
Stenholm S, Metter EJ, Roth GS, Ingram DK, Mattison JA, Taub DD, Ferrucci L. Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore Longitudinal Study of Aging. Aging Clin Exp Res. 23(2):153-8, 2011.
Ingram DK, Roth GS. Glycolytic inhibition as a strategy for developing calorie restriction mimetics. Exp Gerontol. 46:148-54, 2011.
Araujo J, W, de Rivera C, Sandin, J, Greig N, Ingram DK, Milgram NW. Cholinesterase inhibitors improve both memory and complex learning in aged Beagle dogs. J Alzheimers Dis. 26(1):143-55, 2011.
Manaye KF, Allard JS, Kalifa S, Drew AC, Xu G, Ingram DK, Cabo RD, Mouton PR. 17a-Estradiol attenuates neuron loss in ovariectomized dtg APP/PS1 Mice. J Alzheimers Dis. 23(4):629-39, 2011.
Elks CM, Reed SD, Mariappan N, Shukitt-Hale B, Joseph JA, Ingram DK, Francis J. A Blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS One. 6(9):e24028, 2011.
Roth GS, Mattison JA, Ottinger MA, Chachich M, Lane MA, Ingram DK. Aging in rhesus monkeys: Relevance to human health interventions, Science, 305: 1423-1426, 2004.
Mamczarz J, Duffy K, Bowker J, Hagepanos A, Ingram D. Enhancement of amphetamine-induced locomotor response in rats on different regimens of diet restriction and 2-deoxyglucose treatment, Neuroscience, 131: 451-461, 2005.
Mattison J, Black A, Huck, J.,Moscrip T, Handy A,Tilmont T, Roth GS, Lane, MA, Ingram DK. Age-related decline in caloric intake and motivation for food in rhesus monkeys. Neurobiology of Aging, 26: 1117-1127, 2005.
Devan BD, Bowker JL, Bharati IS, Duffy KB, Nelson CM, Spangler EL, Ingram DK. The phosphodiesterase inhibitor sildenafil citrate attenuates the learning impairment in rats induced by nitric oxide synthase inhibition, Psychopharmacology, 183, 439-445, 2006.
Ingram DK, Zhu M, Mamczarz J, Zou S, Lane, MA, Roth GS, de Cabo R. Calorie restriction mimetics: An emerging research field. Aging Cell, 5: 97-108, 2006.
Lee GD, Longo D, Wang Y, Rifkind JM, Abdul-Raman L, Mamczarz JA, Duffy KB, BowkerJL, Spangler EL, Taub DD, Furukawa K, Mattson MP, Ingram DK. Cancer chemotherapy transiently improves cognitive function and synaptic plasticity in rats. Clinical Cancer Research. 12:198-205, 2006.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Vinayakuma VP, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy R, Fishbein KW, Spencer RG, Lakatta EG, LeCourteur D, Shaw RJ, Navas P, Puigerver P, Ingram DK, deCabo R, Sinclair DA. Resveratrol improves health and increases survival of mice on a high-calorie diet. Nature, 444: 337-342, 2006.
Devan, BD, Pistell, PJ, Daffin LW Jr, Nelson CM, Duffy KB, Bowker JL, Bharati IS, Sierra-Mercado D, Spangler EL, Ingram DK. Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor N?-nitro-L-arginine methyl ester. European Journal of Pharmacology, 563:134-140, 2007.
Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, DeCabo R, Mouton PR, Shukitt-Hale BA, Joseph JA, Ingram DK. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiology of Aging, 29: 1680-1689, 2007.
Ingram DK, Young J, Mattison JA. Calorie restriction in nonhuman primates: Assessing effects on brain and behavioral aging. Neuroscience, 145: 1359-1364, 2007.
Mattison JA, Roth GS, Lane MA, Ingram DK. Calorie restriction in aging nonhuman primates. In: Mobbs, C.V., Yen, K., Hof, P.R., (Eds): Mechanisms of Caloric Restriction in Aging. Interdisciplinary Topics in Gerontology Basel, Karger, 2007, vol 35, pp. 137-158.
O'Neil JN, Mouton PR, Tizabi Y, Ottinger MA, Lei DL, Ingram DK, Manaye KF. Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. Journal of Chemical Neuroanatomy 34:102-107, 2007.
Pistell PJ, Daffin LW, Jr, Nelson CM, Duffy KB, Bowker JL, Spangler EL, Ingram DK, Devan BD. Combined administration of subthreshold doses of the nitric oxide inhibitor, nitro-L-arginine, and muscarinic receptor antagonist, scopolamine, impairs complex maze learning in rats. Behavioural Pharmacology.18: 801-805, 2007.
Stote KS, Baer DJ, Spears K, Paul DR, Harris GK, Rumpler WV, Strycular P, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Mattson MP. A controlled trial of reduced meal frequency without caloric restriction in healthy, normal weight middle-aged men and women. American Journal of Clinical Nutrition 85:981-988, 2007.
Minor RK, Villarreal J, McGraw M, Percival SS, Ingram DK, de Cabo R. Calorie restriction alters physical performance but not cognition in two models of altered neuroendocrine signaling. Behavioural Brain Research, 189:202-211, 2008.
Pistell PJ, Zhu M, Ingram DK. Acquisition of conditioned taste aversion is impaired in the APP/PS1 mouse model of Alzheimer’s disease. Neuroscience, 152:594-600, 2008.
Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo M