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Yourka Tchoukalova,
Assistant Professor
Department/Laboratory:
Biology of Adipose Tissue Depots
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Phone:
(225) 763-2774
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EDUCATION
Doctor of Medicine - Medical Academy, Sofia, Bulgaria 1978
Master of Science – Nutrition, BYU, Provo, UT 1996
Doctor of Philosophy – Nutrition, UGA, Athens, GA 2000
RESEARCH INTERESTS
To study adipogenesis [using in vitro (stromovascular cultures) and in vivo (deuteriated water-labeling of DNA from adipocytes and plastic-adherent stromovascular cells] in various fat depots in obesity and conditions of insulin resitance.
SELECTED PUBLICATIONS
1. Tchoukalova YD, Grider A, Mouat MF, Hausman GJ. Priming with magnesium-deficient media inhibits preadipocyte differentiation via potential upregulation of tumor necrosis factor-alpha. Biol Trace Elem Res 74:11-21, 2000.
2. Tchoukalova YD, Hausman DB, Dean RG, Hausman GJ. Enhancing effect of troglitazone on porcine adipocyte differentiation in primary culture: a comparison with dexamethasone. Obes Res 8:664-72, 2000.
3. Tchoukalova YD, Hausman DB, Angelova K, Hausman GJ. Tumor necrosis factor-alpha binding in porcine primary stromal-vascular cell cultures. In Vitro Cell Dev Biol Anim 37:303-9, 2001.
4. Tchkonia T, Giorgadze N, Pirtskhalava T, Tchoukalova Y, Karagiannides I, Forse RA, DePonte M, Stevenson M, Guo W, Han J, Waloga G, Lash TL, Jensen MD, Kirkland JL. Fat depot origin affects adipogenesis in primary cultured and cloned human preadipocytes. Am J Physiol Regul Integr Comp Physiol 282:R1286-96, 2002.
5. Tchoukalova YD, Harteneck DA, Karwoski RA, Tarara J, Jensen MD. A quick, reliable, and automated method for fat cell sizing. J Lipid Res 44:1795-801, 2003.
6. Tchoukalova YD, Sarr MG, Jensen MD. Measuring committed preadipocytes in human adipose tissue from severely obese patients by using adipocyte fatty acid binding protein. Am J Physiol Regul Integr Comp Physiol 287:R1132-40, 2004.
7. Tchkonia T*, Tchoukalova YD*(*equal contribution), Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots. Am J Physiol Endocrinol Metab 288:E267-77, 2005.
8. Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Cartwright A, Cartwright M, Flannagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova YD, Jensen MD, Pothoulakis C, Kirkland JL. Identification of Depot-specific Human Fat Cell Progenitors through Distinct Expression Profiles and Developmental Gene Patterns. Am J Physiol Endocrinol Metab 292(1):E298-307, 2007.
9. Tchoukalova YD, Koutsari C, Jensen MD. Committed Subcutaneous Preadipocytes are Reduced in Human Obesity but Preadipocyte Kinetics Vary by Obesity Phenotype. Diabetologia 50(1):151-7, 2007.
10. Tchoukalova YD, Koutsari C, Karpyak MV, Votruba SB, Wendland E, Jensen MD. Subcutaneous adipocyte size and body fat distribution. Amer J Clin Nutr 87(1):56-63, 2008.
11. Dubois SG, Tchoukalova YD, Heilbronn LK, Albu JB, Kelley DE, Smith SR, Fang X, Ravussin E; The Look AHEAD Adipose Research Group. Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus. Biochem Biophys Res Commun. 367(4):725-728, 2008. (PMCID: PMC2747303)
12. Tchoukalova YD, Nathanielsz PW, Conover CA, Smith SR, Ravussin E. Regional variation in adipogenesis and IGF regulatory proteins in the fetal baboon. Biochem Biophys Res Commun. 2009 13;380(3):679-83. (PMCID: PMC2733229)
13. Pasarica M, Tchoukalova YD, Heilbronn LK, Fang X, Albu JB, Kelley DE, Smith SR, Ravussin E. The Look AHEAD Adipose Research Group. Differential effect of weight loss on adipocyte size subfractions in patients with type 2 diabetes. Obesity (Silver Spring). 2009 17(10):1976-8. (PMCID in process)
14. Tchoukalova YD, Koutsari C, Votruba SB, Tchkonia T, Giorgadze N, Thomou T, Kirkland JL, Jensen MD. Sex- and depot-dependent differences in adipogenesis in normal weight humans. Obesity (Silver Spring). 2010 (in print).
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