Claude Bouchard, Ph.D.

John W. Barton, Sr. Endowed Chair in Genetics and Nutrition
Professor

Department/Laboratory:
Human Genomics
Phone:
(225) 763-2663
 
Fax:
(225) 763-2525
Send E-mail 
 

EDUCATION

B.Ped, Laval University, 1962
M.Sc., University of Oregon, 1963
Postgrad, Institute for Research on Circulation and Sports Medicine, German Sporthochschule and University of Cologne, 1963-65
Ph.D., The University of Texas at Austin, 1977
Postdoc, University of Montreal, 1977

RESEARCH INTERESTS

Dr Bouchard's research interests focus on genetics of obesity and some of the morbidities associated with obesity, including type 2 diabetes and hypertension. He is also studying the role of genetic variation in the adaptation to regular physical activity in terms of cardiorespiratory endurance and changes in cardiovascular disease and type 2 diabetes risk factors. His research benefits from several cohorts of families and relies on physiological, metabolic, and genomics technologies.

SELECTED PUBLICATIONS

Rankinen T, Rice T, Teran-Garcia M, Rao DC, Bouchard C. FTO genotype is associated with exercise training-induced changes in body composition. Obesity 18: 322-26, 2010.

Rankinen T, Argyropoulos G, Rice T, Rao DC, Bouchard C. CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: The HERITAGE Family Study. Circ Cardiovasc Genet 3:294-9, 2010.

Sarzynski MA, Rankinen T, Sternfeld B, Grove ML, Fornage M, Jacobs DR Jr,Sidney S, Bouchard C. Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: The Coronary Artery Risk Development in Young Adults (CARDIA) Fitness Study. Circ Cardiovasc Genet 3: 531-8, 2010.

Bouchard C, Sarzynski MA, Rice TK, Kraus WE, Church TS, Sung YJ, Rao DC, Rankinen T. Genomic predictors of the maximal O2 uptake response to standardized exercise training programs. J Appl Physiol. 110:1160-1170, 2011.

Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjostrom L, Bouchard C, Carlsson LMS. Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes. 35:676-683, 2011.

Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjöström L, Carlsson LM, Bouchard C. Association of GWAS-based candidate genes with HDL-cholesterol levels before and after bariatric surgery in the Swedish Obese Subjects Study. J Clin Endocrinol Metab. 96(6):E953-7, 2011.

Sarzynski MA, Rankinen T, Sternfeld B, Fornage M, Sidney S, Bouchard C. SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study. J Hum Hypertens. 25(8):509-18, 2011.

Bouchard C. Overcoming barriers to progress in exercise genomics. Exerc Sport Sci Rev. 39(4):212-217, 2011.

Choquette AC, Bouchard L, Drapeau V, Lemieux S, Tremblay A, Bouchard C, Vohl MC, Pérusse L. Association between olfactory receptor genes, eating behavior traits and adiposity: Results from the Quebec Family Study. Physiol Behav. 105(3):772-6, 2012.

Sung YJ, Wang L, Rankinen T, Bouchard C, Rao DC. Performance of genotype imputations using data from the 1000 Genomes Project. Hum Hered. 73(1):18-25, 2012.

Rankinen T, Sung YJ, Sarzynski MA, Rice TK, Rao DC, Bouchard C. Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs. J Appl Physiol. 112(5):892-7, 2012.

Bouchard C. Genomic predictors of trainability. Exp Physiol. 97(3):347-52, 2012. PMID: 21967902

Roth SM, Rankinen T, Hagberg JM, Loos RJF, Perusse L, Sarzynski MA, Wolfarth B, Bouchard C. Advances in exercise, fitness, and performance genomics in 2011. Med Sci Sports Exerc. 44(5): 809-17, 2012.

Bouchard C, Blair SN, Church TS, Earnest CP, Hagberg JM, Häkkinen K, Jenkins NT, Karavirta L, Kraus WE, Leon AS, Rao DC, Sarzynski MA, Skinner JS, Slentz CA, Rankinen T. Adverse metabolic response to regular exercise: is it a rare or common occurrence? PLoS One. 7(5):e37887, 2012.

Rice TK, Sarzynski MA, Sung YJ, Argyropoulos G, Stütz AM, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T. Fine mapping of a QTL on chromosome 13 for submaximal exercise capacity training response: the HERITAGE Family Study. Eur J Appl Physiol. 112(8):2969-78, 2012.

Sarzynski MA, Jacobson P, Rankinen T, Carlsson B, Sjostrom L, Bouchard C, Carlsson LMS. Changes in uric acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish Obese Subjects Study. PLoS One. 7(12):e51658, 2012.

Plourde M, Vohl MC, Bellis C, Carless M, Dyer T, Dolley G, Marette A, Després JP, Bouchard C, Blangero J, Pérusse L. A variant in the LRRFIP1 gene is associated with adiposity and inflammation. Obesity (Silver Spring). 21(1):185-92, 2013.

Pérusse L, Rankinen T, Hagberg JM, Loos RJ, Roth SM, Sarzynski MA, Wolfarth B, Bouchard C. Advances in exercise, fitness, and performance genomics in 2012. Med Sci Sports Exerc. 45(5):824-31, 2013.

den Hoed M, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 45(6):621-31, 2013.

Sarzynski MA, Bouchard C. The challenging case for nutrigenetic predictors of metabolic responses to dietary interventions. Diabetes Care. 36:3379-81, 2013.

Ghosh S, Vivar JC, Sarzynski MA, Sung YJ, Timmons JA, Bouchard C, Rankinen T. Integrative pathway analysis of a genome-wide association study of VO2max response to exercise training. J Appl Physiol. 115(9):1343-59, 2013.

Thomas DM, Martin CK, Lettieri S, Bredlau C, Kaiser K, Church T, Bouchard C, Heymsfield SB. Can a weight loss of one pound a week be achieved with a 3500-kcal deficit? Commentary on a commonly accepted rule. Int J Obes (Lond). 37(12):1611-3, 2013.

Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, Souza AL, Clish CB, Wang TJ, Estall JL, Soukas AA, Cowan CA, Spiegelman BM, Gerszten RE. ß-Aminoisobutyric Acid induces browning of white fat and hepatic ß-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 19(1):96-108, 2014.

Thomas DM, Weedermann M, Fuemmeler BF, Martin CK, Dhurandhar NV, Bredlau C, Heymsfield SB, Ravussin E, Bouchard C. Dynamic model predicting overweight, obesity, and extreme obesity prevalence trends. Obesity (Silver Spring). 22(2):590-7, 2014.

Chaput J.-P., Perusse L, Despres J.-P., Tremblay A, Bouchard C. Findings from the Quebec Family Study on the etiology of obesity: Genetics and environmental highlights. Curr Obes Rep. 3:54-66, 2014.

Bouchard C, Tchernof A, Tremblay A. Predictors of body composition and body energy changes in response to chronic overfeeding. Int J Obes (Lond). 38(2):236-42, 2014.

Bray GA, Bouchard C, editors. Handbook of Obesity: Epidemiology, Etiology, and Physiopathology, Third Edition. Boca Raton, FL: CRC Press, 2014.

Bray GA, Bouchard C, editors. Handbook of Obesity: Clinical Applications, Fourth Edition. Boca Raton, FL: CRC Press, 2014. ^ top