Jeffrey Gimble, M.D., Ph.D.
Stem Cell Biology
M.D., Yale Univesity, New Haven, CT, 1982
Ph.D., Yale University, New Haven, CT, 1981, Cell Biology
M.A., Yale University, New Haven, CT, 1980, Cell Biology
B.A., Dartmouth College, Hanover, NH,1973-1976, Biology/Chemistry
Dr. Gimble's laboratory focuses on the isolation and characterization of adult stem cells from adipose tissue and bone marrow. These stromal cells have multiple differentiation potential and are capable of forming adipocytes, chondrocytes, hematopoietic supporting cells, neuronal cells, and osteoblasts in vitro. We are exploring the regulatory mechanisms governing the adult stem cell's fate and how they can be applied to regenerative medical problems.
Aust L, Devlin BH, Foster SJ, Halvorsen YDC, Hicok K, Kloster AL, du Laney TV, Sen A, Willingmyre D, Gimble JM. Recovery of Human Adipose Derived Adult Stem Cells from Liposuction Aspirates. Cytotherapy 6:7-14, 2004.
Awad HA, Wickham MQ, Leddy HA, Gimble JM, Guilak F. Chondrogenic Differentiation of Adipose-Derived Adult Stem Cells in Agarose, Alginate, or Gelatin Scaffolds. Biomaterials 25:3211-3222, 2004.
Hicok K, du Laney T, Sheng Zhou Y, Halvorsen Y-DC, Hitt CD, Cooper LF, Gimble JM. Human Adipose Derived Adult Stem Cells Produce Osteoid In Vivo. Tissue Engineering 10:371-380, 2004.
Safford, K. M., Safford, S. D., Gimble, J. M., Shetty, A. K., and Rice, H. E. Characterization of neuronal/glial differentiation of murine adult adipose-derived stromal cells. Experimental Neurology 187:319-28, 2004.