Zhanguo Gao, Ph.D.

Assistant Professor

Antioxidant and Gene Regulation Lab
(225) 763-3023
(225) 763-0274
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Beijing Medical University, Beijing, PR China, 1999, PhD


Our research focuses on HDAC inhibitors in the regulation of insulin sensitivity and cardiovascular disease using the cellular and transgenic mouse models.


• Gao Z, Ye JP. Why do anti-inflammatory therapies fail to improve insulin sensitivity? Acta Pharmacol Sin 33: 182-8, 2012.
• Li H, Gao Z, Zhang J, Ye X, Xu A, Ye J, Jia W. Sodium Butyrate Stimulates Expression of Fibroblast Growth Factor 21 in Liver by Inhibition of Histone Deacetylase 3. Diabetes. 61(4):797-806. 2012
• Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem 286: 22227-34, 2011.
• Zhang J, Henagan TM, Gao Z, Ye J. Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. Endocrinology. 152(5):1829-38, 2011. PMCID: PMC3075929
• Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 58: 1509-17, 2009.
• Gao Z, Yin J, Zhang J, He Q, McGuinness OP, Ye J. Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K. J Biol Chem 284: 18368-76, 2009.
• Gao Z, Yin J, Zhang J, Ward RE, Martin R, Lefevre M, Cefalu W and Ye J: Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice. Diabetes 58:1509-1517, 2009. PMCID: PMC2699871
• Gao Z, Ye J. Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem Biophys Res Commun 376: 793-6, 2008.
• Gao Z, Wang Z, Zhang X, Butler AA, Zuberi A, Gawronska-Kozak B, Lefevre M, York D, Ravussin E, Berthoud HR, McGuinness O, Cefalu WT, Ye J. Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice. Am J Physiol Endocrinol Metab 292: E84-91, 2007.
• Gao Z, He Q, Peng B, Chiao P and Ye J: Regulation of Nuclear Translocation of HDAC3 by IkBa Involves in TNF-inhibition of PPARg Function. Journal of Biological Chemistry. 281:4540-4547, 2006. PMCID: PMC1447600
• Gao Z, Chiao P, Zhang X, Zhang X, Lazar M, Seto E, Young HA, Ye J. Coactivators and corepressors of NF-kB in IkBa gene promoter. Journal of Biological Chemistry, 280(22):21091-21098, 2005. PMCID: PMC1237005
• Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol. 18(8):2024-34, 2004
• Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem. 4; 278(27):24944-50. 2003
• Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem. 13;277(50):48115-21, 2002
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