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  Class Meetings: Wednesdays 3:40-5:30 pm
Presentation Room (Administration Building, 2nd Floor, next to elevator)
Pennington Biomedical Research Center
  Course Description: The development of current concepts of nutritional effects on health and disease though the use of cellular, molecular, genetic, and epidemiological tools.
  Prerequisites: BIOL 4087 or BIOL 4094 or permission of the coordinator
  Instructors: This course will be team-taught using the specific expertise of Pennington Biomedical Research Center staff in each topic area. Dr. Roy Martin, Director, School of Human Ecology, will be the instructor of record for the course and will liaise with each topic coordinator to ensure a uniformity of approach. The Division of Educational Programs at Pennington will coordinate the course.
    Roy J. Martin, Ph.D.
Room 129
Human Ecology Building
Louisiana State University
Baton Rouge, LA
(225) 578-2284 		Division of Educational Programs
Room G2006
Pennington Biomedical Research Center
6400 Perkins Road
Baton Rouge, LA
(225) 763-3046
  Objectives: During and upon successful completion of the course, students will be able to:

1. Describe current understanding of specific topics in the field of molecular and clinical nutrition.
2. Explore interactions between basic and clinical sciences in developing their understanding of nutritional effects.
3. Discuss how modern cellular and molecular techniques are used to identify mechanisms of nutrient action.
4. Outline appropriate experimental approaches for the design of clinical research studies.
5. Explain the role of gene/environment interactions in the maintenance of health and the development of disease.
6. Discuss the effects of nutrition at different organizational levels from the whole body through organs and cells to the genome.
  Assignments and Evaluation:

Each instructor will formulate an exam question that captures a key point of their lecture. These will be given to students in the form of a take home exam.

Grading:
A 90 – 100
B 80 – 89
C 70 – 79
D 60 – 69
F < 60
 

 

Due to size, some of the presentations have been converted to PDF format for fast downloading. You must have Adobe Acrobat Reader to view these files.
To save slides to disk: Right Click the link and Choose "Save Target As"

Date Topic Instructor PowerPoint/PDF Slides
Jan 21 Impact of Early Nutrition on Health and Disease M. Sothern sothern.ppt
Jan 28 Nutrition, Reproduction and Aging W. Hansel  
Feb 4 Transcriptional Control of Adipose Tissue Development J. Stephens  
Feb 11 Nutrition and Immune Function J. Gimble Gimble.doc
Feb 18 Heritability of Chronic Diseases T. Rankinen Rankinen.ppt
Feb 25 NO CLASS - Mardi Gras Holiday    
Mar 3 Genetics of Type II Diabetes
E. Ravussin Ravussin.pdf
Mar 10 Genetics of Obesity C. Bouchard Bouchard.ppt
Mar 17 Nutrition and Obesity G. Bray  
Mar 24 Nutrition and Atherosclerotic Cardiovascular Disease M. Lefevre  
Mar 31 Nutrition and Hypertension D. Harsha  
Apr 7 NO CLASS - Spring Break    
Apr 14 Integrated Control of Feeding Behavior W. Cassidy  
Apr 21 Nutrition and Diabetes W. Cefalu  
Apr 28 Nutrition and Cancer E. Hardman Hardman.ppt
May 5 Assessment of Nutritional Status and Behavorial Aspects of Nutrition Interventions C. Champagne
P. Brantley 		 
  FINAL EXAM BETWEEN MAY 10-15    

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Instructor Readings
M. Sothern

Barker DJ, Eriksson JG, Forsen T, Osmond C. Fetal origins of adult disease: Strength of effects and biological basis. International Journal of Epidemiology . 2002;31(6):1235-9.

Newsome CA, Shiell AW, Fall CH, Phillips DI, Shier R, Law CM. Is birth weight related to later glucose and insulin metabolism - A systematic review. Diabetic Medicine . 2003;20(5):339-348.

Sothern MS, Gordon ST. Prevention of obesity in young children: A critical challenge for medical professionals. Clinical Pediatrics . 2003;42(2):101-111.
W. Hansel

Atwood CS, Barzilai N, Bowen RL, Brown-Borg HM, Jarrard DF, Fu VX, Heilbronn LK, Ingram DK, Ravussin E, Schwartz RS, Weindruch R. Pennington scientific symposium on mechanisms and retardation of aging. Experimental Gerontology . 2003;38(10):1217-1226.

McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of the life span and upon ultimate body size. The Journal of Nutrition . 1935; 10:63-79.

J. Stephens

 
J. Gimble

Cunningham-Rundles S, Lin DH. Nutrition and the immune system of the gut. Nutrition. 1998; 14(7-8): 573-579.

Keusch GT. The history of nutrition: Malnutrition, infection and immunity. The Journal of Nutrition. 2003;133(1): 336S-340S.

http://press2.nci.nih.gov/sciencebehind/immune/immune00.htm

http://www.biology.arizona.edu/immunology/tutorials/immunology/page2.htm

Background Information
Semba RD, Tang AM. Micronutrients and the pathogenesis of human immunodeficiency virus infection. British Journal of Nutrition . 1999; 81(3):181-189.

Scrimshaw NS. Historical concepts of interactions, synergism and antagonism between nutrition and infection. The Journal of Nutrition . 2003; 133(1): 316S-321S.
T. Rankinen  
E. Ravussin

Rutherford S, Shuldiner AR, Mitchell BD. Genome scans of diabetes mellitus. In RA DeFronzo, E Ferrannini, H Keen, P Zimmet (Eds.), International Textbook of Diabetes Mellitus , 3 rd edition. In press.

Sabra MM, Shuldiner AR, Silver KD. Candidate genes for type 2 diabetes mellitus. In D LeRoith, JM Olefsky, SI Taylor (Eds.), Diabetes Mellitus: A Fundamental and Clinical Text, 3 rd Edition. In press.
C. Bouchard

Loos RJF, Bouchard C. Obesity – is it a genetic disorder? Journal of Internal Medicine . 2003; 254(5):401-425.

Chagnon YC, Rankinen T, Snyder EE, Weisnagel SJ, Perusse L, Bouchard C. The human obesity gene map: The 2002 update. Obesity Research. 2003; 11(3): 313-367.
M. Lefevre  
G. Bray

Book to be distributed in class.

Bray GA. Contemporary Diagnosis and Management of Obesity. Newtown, PA: Handbooks in Health Care, 2 nd Edition, 2003.
D. Harsha

Appel LJ. Lifestyle modification as a means to prevent and treat high blood pressure. Journal of the American Society of Nephrology . 2003; 14: S99-S102.

Suter PM, Sierro C, Vetter W. Nutritional factors in the control of blood pressure and hypertension. Nutrition in Clinical Care . 2002; 5(1):9-19.

Zimmerman E, Wylie-Rosett J. Nutrition therapy for hypertension. Current Diabetes Report . 2003; 3:404-411.
W. Cassidy

 
W. Cefalu

Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. The New England Journal of Medicine . 2002; 346(6): 393-403.

Weyer C, Bogardus C, Mott DM, Pratley RE. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. The Journal of Clinical Investigation . 1999; 104(6): 787-794.

Weyer C, Tataranni PA, Bogardus C, Pratley RE. Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care. 2001: 24(1); 89-94.

E. Hardman

Wargovich MJ, Cunningham JE. Diet, individual responsiveness and cancer prevention. The Journal of Nutrition . 2003; 133(7 Suppl): 2400S-2403S.

Lampe JW. Spicing up a vegetarian diet: Chemopreventive effects of phytochemicals. American Journal of Clinical Nutrition . 2003; 78(3 Suppl): 579S-583S.

Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. American Journal of Clinical Nutrition . 2003; 78(3 Suppl): 559S-569S.

Hardman, WE. Omega-3 fatty acids to augment cancer therapy. The Journal of Nutrition . 2002; 132(11 Suppl): 3508S-3512S.

C. Champagne

Biro G, Hulshof KF, Ovesen L, Amorim Cruz JA; EFCOSUM Group. Selection of methodology to assess food intake. European Journal of Clinical Nutrition . 2002; 56 (Suppl 2): S25-S32.

Livingstone MBE, Black AE. Markers of the validity of reported energy intake. Journal of Nutrition. 2003; 133 (Suppl 3): 895S-920S.
P. Brantley

Wing RR. 1998. Behavioral approaches to the treatment of obesity. In GA Bray, C Bouchard, & WPT James (Eds.), Handbook of obesity (pp. 855-873). New York: Marcul Dekker, Inc.

Kumanyika SK, Van Horn L, Bowen D, Perri MG, Rolls BJ, Czajkowski SM, Schron E. Maintenance of dietary behavior change. Health Psychology . 2000; 19:42-56

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