MOLECULAR AND CLINICAL NUTRITION I

Schedule of Classes | Recommended Readings | Midterm/Final Exam Questions

Online Syllabus
Download & Print it

Class Meetings:

Mondays 3:10 - 5:00 pm
Conference Center Room 326 until September 26th.
s After the 26th classes will be held in the Administration Building Auditorium.
Pennington Biomedical Research Center
6400 Perkins Road
Baton Rouge, LA 70808

Course Description:

The development of current concepts of nutritional effects on health and
disease through the use of cellular/molecular tools.

Prerequisites:

BIOL 4087 or BIOL 4094 or permission of the coordinator

Instructors:

This course will be team-taught using the specific expertise of Pennington Biomedical Research Center staff in each topic area. Dr. Roy Martin, Director, School of Human Ecology, will be the instructor of record for the course and will liaise with each topic coordinator to ensure a uniformity of approach. The Division of Educational Programs at Pennington will coordinate the course.

Roy J. Martin, Ph.D.
Room 129
Human Ecology Building
Louisiana State University
Baton Rouge, LA
(225) 578-2284

Division of Educational Programs
Room G2004
Pennington Biomedical Research Center
6400 Perkins Road
Baton Rouge, LA
(225) 763-2629

Text:

Recommended readings noted below.
Readings will be on file in the Pennington Library as well as the Middleton Library by Friday 8/19

Objectives:

During and upon successful completion of the course, students will be able to:

1. Identify current understanding of specific topics in the field of molecular and clinical nutrition.
2. Explore interactions between basic and clinical sciences in developing their understanding of nutritional effects.
3. Discuss how modern cellular and molecular techniques are used to identify mechanisms of nutrient actions.
4. Explain the role of gene/environment interactions in the maintenance of health and the development of disease.
5. Outline the mechanisms through which the brain integrates energy intake and peripheral metabolism.
6. Discuss the effects of nutrition at different organizational levels from the whole body through organs and cells to the genome.

Assignments and Evaluation:

Each instructor will formulate exam questions that addresses key points of their lecture. These will be given to students in the form of a take home exam.

Grading:
A: 90 – 100: Outstanding
B: 80 – 89: Pass
C: 79 >

Schedule of Classes:

Due to size, some of the presentations have been converted to PDF format for fast downloading. You must have Adobe Acrobat Reader to view these files.
To save slides to disk: Right Click the link and Choose "Save Target As"

Date	Topic	Instructor	Notes
Aug 22	Overview of Signaling inputs to nutrient partitioning and metabolic regulation	Tom Gettys, Ph.D.	Gettys05.ppt
Aug 29
Sept 5	Labor Day Holiday
Sept 12	Insulin Resistance and Type 2 Diabetes	Eric Ravussin, Ph.D.
Sept 19	Insulin Signaling Mechanisms in Adipose Tissue	Jianping Ye, M.D.
Sept 26
Oct 3	Regulation of Substrate Utilization, Triglyceride Synthesis, Fatty Acid Oxidation, & Expression of Associated Genes	Steve Smith, M.D.	Smith05.pdf
Oct 6	Adipose Tissue as Endocrine Organ and Influence of Metabolism and Food Intake	Randy Mynatt, Ph.D.
Oct 10	Review/Mid Term Exam Due	Roy Martin, Ph.D.
Oct 17	ANS Functioning	Kirsteen Browning, Ph.D.	Browning05.ppt Figure11-11.ppt Figure11-5.ppt
Oct 24	Lipoprotein Assembly and Metabolism	Mike Lefevre, Ph.D.	Lefevre05.ppt
Oct 31	Fatty acid oxidation and lipid metabolism Particularly Role of Amino Acids and Signaling	Matthew Hulver, Ph.D.
Nov 7	Neural Control of Food Intake and Energy Expenditure	Hans-Rudolf Berthoud, Ph.D.
Nov 14	Integrated Control of Energy Expenditure	Leslie Kozak, Ph.D.
Nov 21	Diurnal Rhythms	Jeff Gimble, M.D., Ph.D.
Nov 28	The Dark Side: Disease and Cachexia States	Gerlinda Hermann, Ph.D.
Dec 5	Essentials of Nutrient Detection by the Nervous System	Roy Martin, Ph.D.

Midterm/Final Exam Questions :

Midterm/Final Exam Questions are in Microsoft Word Format.

MIDTERM QUESTIONS

FINAL EXAM QUESTIONS

Recommended Readings:

Readings will be on file in the Pennington Library as well as the Middleton Library by Friday 8/19

Date	Readings
August 22	Gettys, T.W., Mills, S., Henricks, D.M. An evaluation of the relation between food consumption rate and equilibrium body-weight in male rats. Brit. J. Nutr . 60: 151-160, 1988. Morris, A.M., Calsbeek, D.J., and Eckel, R.H. Lipid metabolism and nutrient partitioning strategies. Curr. Drug Targets CNS Neurol. Disord . 3: 411-430, 2004. Lewis, G.F., Carpentier, A., Adeli, K., and Giacca, A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr. Rev . 23: 201-229, 2002. Beebe, S.J., Redmon, J.B., Blackmore, P.F., and Corbin, J.D. Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis. J. Biol. Chem . 260:15781-15788, 1985. Zmuda-Trzebiatowska, E., Oknianska, A., Manganiello, V., and Degerman, E. Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes. Cell Signaling ( in press - I will get the citation when it becomes available) 2005.
August 29	Coleman, R., Lewin, T., and Muoio, D. Physiological and nutritional regulation of enzymes of triacylglycerol synthesis. Annu Rev Nutr 20:77-103, 2000. Ruderman, N.B., Saha, A.K., Vavvas, D., and Witters, L.A. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 276:E1-E18, 1999. Simoneau, J.A., Veerkamp, J.H., Turcotte, L.P., and Kelley, D.E. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. Faseb J 13:2051-2060, 1999.
September 5	HOLIDAY
September 12	McGarry J.D. Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes, Diabetes 51; 718, 2002. Ravussin E., Smith S.R. Increased Fat Intake, Impaired Fat Oxidation and Failure of Fat Cells Proliferation Result in Ectopic Fat Storage, Insulin Resistance and Type 2 Diabetes. Annals of the New York Academy of Sciences 967:363-378, 2002. Bergnan, R.N., Hucking, K., Watanabe, R.M. International Textbook of Diabetes Mellitus, Third Edition, 2004, “Measuring Insulin Action In Vivo ”, 303-318.
September 19	Saltiel, A.R., Kahn, C.R. Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414:799-806, 2001. White, M.F. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 283:E413-422, 2002. Lazar, M.A.. How obesity causes diabetes: not a tall tale. Science 307:373-375, 2005.
September 26	Lau , D.C. , Dhillon, B., Yan H., Szmitko, P.E., Verma, S. Adipokines: molecular links between obesity and atherosclerosis. Am J Physiol Heart Circ Physiol . 2005. May; 288(5):H2031-41. Epub Jan 14, 2005. Kershaw, E.E., Flier, J.S. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab .. Jun; 89(6) 2548-56, 2004.
October 3	Jeukendrup A.E. Regulation of fat metabolism in skeletal muscle. Ann N Y Acad Sci 967:217-235, 2002.
October 5	Review/Mid Term Exam due
October 17	Efferent Division: autonomic and somatic motor control. Chapter 11 in “Human Physiology. An Integrated Approach” edited by Dee Unglaub Silverthorn Benjamin Cummings (2004) 3rd edition ISBN 0-13-10235-3. Saper, C.B. The Central Autonomic Nervous System: conscious visceral perception and autonomic pattern generation. Ann Rev Neurosci 25: 433-469, 2002. Grundy D (2002) Neuroanatomy of visceral nociception: vagal and splanchnic afferent. Gut 51 (Suppl 1) i2-i5 Powley, T.J., Phillips, R.J. Musings on the Wanderer: What's new in our understanding of vago-vagal reflex? I. Morphology and topography of vagal afferents innervating the GI tract. Am. J. Physiol. 283, G1217-G1225, 2002. Browning, K.N., Mendelowitz, D. Musings on the Wanderer: What's new in our understanding of vago-vagal reflex? II Integration of afferent signaling from the viscera by the nodose ganglia. Am. J. Physiol. 284 G8-G14, 2003. Travagli, R.A., Hermann, G.E., Browning, K.N., Rogers , R.C. Musings on the Wanderer: What's new in our understanding of vago-vagal reflex? III. Activity- dependent plasticity in vago-vagal reflexes controlling the stomach. Am. J. Physiol. 284, G180-G187, 2003. Chang, H.Y., Mashimo, H., Goyal, R.K. Musings on the Wanderer: What's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am. J. Physiol 284, G357-G366, 2003.
October 24	Schaefer, E.J. Lipoproteins, nutrition, and heart disease. Am. J. Clin. Nutr . 75: 191- 212, 2002.
October 31	Kim, M.S., Lee, U. Role of hypothalamic 5'-AMP-activated protein kinase in the regulation of food intake and energy homeostasis. J Mol Med . Jul;83 (7):514- 20, 2005.
November 7	Schwartz, M.W., Niswender, K.D. Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance? J Cin Endocrinol Metabolism 89:5889-5897, 2004. Kelley, A.E., Berridge, K.C. The Neuroscience of Natural Rewards: Relevance to Addictive Drugs. J. Neurosci , 22:3306-3311, 2002.
November 14	Egger, G, Liang, G., Aparicio, Jones, P.A. Epigenetics in human disease and prospects for epigenteic therapy. Nature 429:457-463, 2004. MacDougald, O. and Mandrup, S. Adipogenesis: Forces that tip the scales. Trends in Endocrinol and Metabol. 13:5-11, 2002. Stock, M. Gluttony and theromogenesis revisited. Intl. J. of Obesity 23:1105- 1117, 1999. Kozak, L.P. and M.E. Harper. Mitochondrial uncoupling proteins in energy expenditure. Annu. Rev. Nutr. 20: 339-363, 2000. Lowell , B.B. and E.S. Bachman. {beta}-Adrenergic Receptors, Diet-induced Thermogenesis, and Obesity. J Biol Chem 278(32): 29385-29388, 2003. Lowell , B.B. and B.M. Spiegelman. Towards a molecular understanding of adaptive thermogenesis. Nature 404, #6778: 652-60, 2000.
November 21	Hirota, T., Fukada, Y. Resetting Mechanism of Central and Peripheral Circadian Clocks in Mammals. Zoological Science 21:359-368, 2004. Turek, F.W., Joshu, C., Kohsaka, A., Lin E., Ivanova, G., McDearmon, E., Leposky, A., Lossee-Olson, S, Easton , A., Jensen, D.R., Eckel, R.H., Takahashi, J.S., Bass, J. Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice. Science 308:1043- 1045; May 13, 2005.
November 28	Plata-Salaman, C.R. Central Nervous System Mechanisms contributing to the cachexia-anorexia syndrome. Nutrition 16:10, 2002. Tracey, K.J., Cerami, A. Tumor Necrosis Factor: A pleiotropic cytokine and therapeutic target. Annu. Rev. Med . 45:491-503, 1994.