Study Type

Alzheimer's Disease

Study Purpose

The purpose of this research study is to determine the effects of walking and/or cognitive remediation therapy (CRT) as a way of slowing cognitive decline and decreasing fall risk in the elderly with mild cognitive impairment.

About the Study

The number of steps per day and overall physical activity decreases with older age. Lack of physical activity has been linked significantly to increased morbidity and death in the elderly. Studies have shown that there is a relationship between increased sedentary behavior and increased falls and dementia in the elderly. Finding ways to reliably and effectively combat the negative effects of sedentary behavior, via increased physical activity, may therefore be an inexpensive and reliable therapeutic option for reducing dementia and falls in the elderly.

Study Design

Number of visits:

  • 1 Screening visit
  • 6 Visits to PBRC Fitness Center (every other week for 12 weeks)
  • 2 Follow-up visits at the PBRC Outpatient Clinic (Month 3 and Month 6)

Study procedures:

  • DNA testing via buccal swab
  • Height, weight, vitals EKG
  • Medical history/physical exam
  • Physical performance battery
  • Cognitive testing
  • GAITRite assessment
  • Questionnaires
  • Accelerometer application

Eligible participants will be randomly assigned to one of four groups:

  • Walking Intervention group (WI)
  • Cognitive Remediation Therapy group (CRT)
  • Combination therapy group (WI/CRT)
  • Healthy living group
The interventions will take place in the subject’s home (via internet) and in the PBRC Fitness Center for 12 weeks.  Follow up visits will occur at the PBRC Outpatient Clinic at the end of intervention (month 3) and again at month 6. All study-related procedures will be provided at no cost to the participant.

Study Qualifications

Age: 65-85 years old

Study Duration

6 months



Study Contact

If you are interested in volunteering for the WALKCOG-MCI study, contact Rob Brouillette at (225) 763-0277.


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