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Mentor Bio
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Thomas Gettys, Ph.D.
PI, Pennington Center of Biomedical Research Excellence
Professor
Department/Laboratory:
Laboratory of Nutrient Sensing and Adipocyte Signaling
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Phone:
(225) 763-3165
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Fax:
(225) 763-0274 |
Send
E-mail
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Education:
Ph.D., Clemson University, Clemson, SC, 1984, Nutrition/Physiology
Postdoctoral Training, Vanderbilt University School of Medicine & Howard Hughes Medical Institute, Nashville, TN, Molecular Physiology
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Research
Interests:
Dr. Gettys has a broad interest in the signaling systems which link cell surface receptors to transcriptional programs regulating the metabolic and endocrine functions of adipose tissue. An additional area of interest includes the nutrient sensing mechanisms linking modulation of specific subsets of genes by dietary constituents.
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Selected
Publications:
Zhang, Y., Kilroy, G.E., Henagan, T.M., Prpic-Uhing, V., Richards, W.G., Bannon, A.W., Mynatt, R.L., and Gettys, T.W. 2005. Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin. FASEB J. 19: 1482-1491.
Lenard, N.R., Prpic, V., Adamson, A., Rogers, R.C., and Gettys, T.W. 2006. Differential coupling of mouse ß3A- and ß3B-adrenergic receptors to endogenous and chimeric Gas and Gai. American Journal of Physiology 291: E704-715.
Morrison, C.D., White, C., Wang, Z., Lee, S.Y., Lawrence, D.S., Cefalu, W.T., Zhang, Z.Y., and Gettys, T.W. 2007. Increased hypothalamic PTP1B contributes to leptin resistance with age. Endocrinology 148: 433-440.
Teran-Garcia, M., Adamson, A.W., Yu, G., Rufo, C., Suchankova, G., Clarke, S.D., and Gettys, T.W. 2007. Polyunsaturated fatty acid suppression of fatty acid synthase (FAS): evidence for dietary modulation of SREBP-1c and NF-Y interactions which regulate in vivo binding of NF-Y to the FAS promoter. Biochemical Journal 402: 591-600.
Stewart, L.K., Wang, Z., Ribnicky, D., Soileau, J.L., Cefalu, W.T., and Gettys, T.W. 2009. Failure of dietary quercetin to ameliorate the progression of tissue-specific insulin resistance in C57BL/6 mice weaned onto high fat diets. Diabetologia 52:514-23.
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