| Cancer - William Hansel |
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Faculty:
Andy Deutsch, Vijay Hegde
The DNA Damage & Repair laboratory's mission is to understand genomic instability and its impact on aging and cancer etiology. |
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| Diabetes - William Cefalu |
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Faculty:
Jianping Ye, Zhanguo Gao
website: http://labs.pbrc.edu/generegulation
The Antioxidant and Gene Regulation lab's mission is to understand the cellular and molecular mechanisms of insulin resistance with long-term goal of identification of novel therapeutic targets for type 2 diabetes. |
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Faculty:
William Cefalu, Zhong Wang
website: http://brc.pbrc.edu
The primary mission of the Diabetes and Nutrition laboratory is to study the cellular mechanisms contributing to the development of insulin resistance in humans. In addition, their goal is to evaluate the clinical effect and mechanism of action by which dietary factors modulate insulin resistance. |
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Faculty:
Irina Obrosova,
The Mechanisms of Diabetes Complications laboratory's mission is to understand the pathogenesis of diabetes complications, especially neuropathy. |
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| Experimental Obesity - TBA |
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Faculty:
Aamir Zuberi
The Functional Genomics laboratory is identifying and characterizing important and unknown polymorphic genes that influence susceptibility to dietary obesity and adipogenesis. |
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Faculty:
Randall Mynatt, Jingying Zhang
The Agouti Research Lab uses an integrative approach to understand the actions of the agouti protein and diet in obesity and diabetes. |
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Faculty:
Nikhil Dhurandhar
The Infection and Obesity laboratory's mission is to understand obesity of infectious origin. |
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Faculty:
Vishwa Dixit
There is no description available at this time. Please check back later. |
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| Human Genomics - Claude Bouchard |
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Faculty:
The main focus of research the Energy Balance Laboratory is the regulation of
food intake by central and peripheral agents. |
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Faculty:
Claude Bouchard, Tuomo Rankinen,
website: http://labs.pbrc.edu/humangenomics/
This lab investigates the genetic and molecular basis
of the response to a physically active lifestyle
with an emphasis on cardiorespiratory endurance, cardiovascular disease, and type 2
diabetes risk factors, as well as genetic and
molecular background of obesity and
abdominal obesity and their co-morbidities. |
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| Molecular Genetics - Leslie Kozak |
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Faculty:
Robert Koza
There is no description available at this time. Please check back later. |
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Faculty:
Leslie Kozak, Robert Koza,
The Molecular Genetics and Thermogenesis laboratory is understanding biological processes associated with the obesity problem. |
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Faculty:
The Neuropeptides laboratory's mission is to understand the regulation of the balance of energy intake and energy expenditure by melanocortins. |
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Faculty:
Michael Salbaum
There is no description available at this time. Please check back later. |
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Faculty:
Brenda Richards (Smith)
This laboratory investigates the genetic
basis for variation in the preferential
consumption of dietary fat or carbohydrate,
as well as total energy intake. |
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| Neuroscience - Weihong Pan |
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Faculty:
Jeffrey Keller
There is no description available at this time. Please check back later. |
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Faculty:
Richard Rogers, Gerlinda Hermann, Maria Barnes
The Autonomic Neuroscience Lab has been interested in the relationship between the brain and the digestive tract for more than 20 years. Lately,
they have concentrated on how specific
neural circuits in the brainstem integrate
visceral afferent, descending neural
command, hormone and cytokine signals to
control digestive processes. |
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Faculty:
Weihong Pan
website: http://labs.pbrc.edu/bloodbrainbarrier
The Blood Brain Barrier I Laboratory's primary objective is to identify mechanisms, regulation, and clinical applications of cytokine transport across the blood-brain and blood-spinal cord barrier (BBB). |
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Faculty:
Abba Kastin,
The Blood Brain Barrier II Laboratory's primary objective is to determine the role of the blood-brain barrier (BBB) in neuroendocrine control, particularly in feeding behavior and alcoholism. |
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Faculty:
Roy Martin,
The theme of the Neurobehavior laboratory is “Nutrient (macronutrient) sensing mechanisms are important in the control of feeding behaviors.” Our goal is to modulate nutrient sensing mechanisms to control food intake and obesity. |
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Faculty:
Hans-Rudolf Berthoud, Huiyuan Zheng
The Neurobiology & Nutrition I laboratory's mission is to understand Neural mechanisms of nutrient detection, control of appetite and regulation of energy balance. |
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Faculty:
Christopher Morrison
The Neurosignaling Laboratory focuses on
the cellular mechanisms underlying the
neural regulation of body weight
homeostasis, with particular interest in the
signaling molecules and neuronal circuits
involved in the brain’s “perception” of
nutritional state and subsequent regulation of
feeding behavior. |
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Faculty:
Gregory Holmes
The Neurotrauma & Nutrition laboratory's mission is to understand the effects of spinal cord injury upon GI reflexes and metabolism. |
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| Nutrient Sensing - Thomas Gettys |
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Faculty:
Thomas Gettys
The Adipocyte Signaling lab investigates central mechanisms regulating SNS outflow to adipose tissue, mechanisms of SNS-dependent remodeling of adipose tissue, and functional consequences of adipose tissue remodeling |
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Faculty:
Steven Smith, Yourka Tchoukalova,
website: http://labs.pbrc.edu/endocrinology
The Endocrinology laboratory's mission is to harness multiple experimental approaches to understand the physiological, cellular and molecular connections between diets, particularly those high in fat, and the development of insulin resistance, a precursor to type 2 diabetes. |
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Faculty:
Eric Ravussin, Steven Smith
The Skeletal Muscle Metabolism laboratory is focused on the measurement of skeletal muscle metabolism and seeks to understand and characterize the role of metabolic proteins and mitochondrial dysfunction in metabolic diseases including obesity, diabetes, insulin resistance and some muscle defects that occur with aging (sarcopenia and oxidative stress). Central to this investigation is the rhomboid mitochondrial protease named PARL and the adiponectin/AdipoR axis. |
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Faculty:
There is no description available at this time. Please check back later. |
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Faculty:
Indu Kheterpal
There is no description available at this time. Please check back later. |
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| Stem Cell Biology - Jeffrey Gimble |
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Faculty:
Kenneth Eilertsen
The Epigenetics & Nuclear Reprogramming laboratory investigates 1) the epigenetic basis of nutritional programming that may occur in utero and contribute to later in life diseases such as obesity, hypertension and type 2 diabetes; 2) methods that reprogram the epigenome in ways that restore developmental and differentiation potential; and 3) epigenetic basis of liposarcoma differentiation. |
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Faculty:
Barbara Kozak
The Regenerative Biology Laboratory seeks to understand how tissues and organs can be rebuilt after injury or damage. |
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Faculty:
Jeffrey Gimble
The Stem Cell Biology Laboratory will focus on the characterization and understanding of adipose tissue, adult stem cells and especially the formation and development of adult stem cells. |
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Faculty:
Elizabeth Floyd
There is no description available at this time. Please check back later. |
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